aniracetam

Ligand id: 4133

Name: aniracetam

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 46.61
Molecular weight 219.09
XLogP 1.37
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes
IUPAC Name
1-[(4-methoxyphenyl)carbonyl]pyrrolidin-2-one
International Nonproprietary Names
INN number INN
4902 aniracetam
Database Links
CAS Registry No. 72432-10-1 (source: Scifinder)
ChEMBL Ligand CHEMBL36994
DrugBank Ligand DB04599
GtoPdb PubChem SID 178100955
PubChem CID 2196
RCSB PDB Ligand 4MP
Search Google for chemical match using the InChIKey ZXNRTKGTQJPIJK-UHFFFAOYSA-N
Search Google for chemicals with the same backbone ZXNRTKGTQJPIJK
Search PubMed clinical trials aniracetam
Search PubMed titles aniracetam
Search PubMed titles/abstracts aniracetam
Search UniChem for chemical match using the InChIKey ZXNRTKGTQJPIJK-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone ZXNRTKGTQJPIJK
Wikipedia Aniracetam
Comments
Based on this compound's allosteric action on AMPA receptor activity [1] it was used as the structural basis for the development of novel potential ampakines. These compounds are being investigated as nootropics and neuroprotective drugs for the treatment of Alzheimer's disease (AD) and other neurodegenerative conditions (see patent US6730677).