AZD1480

Ligand id: 5933

Name: AZD1480

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 104.3
Molecular weight 348.1
XLogP 2.22
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
5-chloro-2-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-4-N-(3-methyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine
Synonyms
AZD 1480 | AZD-1480
Database Links
CAS Registry No. 935666-88-9
ChEMBL Ligand CHEMBL1231124
PubChem CID 16659841
RCSB PDB Ligand AZ5
Search Google for chemical match using the InChIKey PDOQBOJDRPLBQU-QMMMGPOBSA-N
Search Google for chemicals with the same backbone PDOQBOJDRPLBQU
Search UniChem for chemical match using the InChIKey PDOQBOJDRPLBQU-QMMMGPOBSA-N
Search UniChem for chemicals with the same backbone PDOQBOJDRPLBQU
Comments
AZD1480 is a novel ATP-competitive inhibitor of JAK1 and JAK2 [2]. This compound is included in AstaZeneca's Open Innovation Pharmacology Toolbox.