AZD1480

Ligand id: 5933

Name: AZD1480

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 104.3
Molecular weight 348.1
XLogP 2.22
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Janus kinase 1 Inhibitor Inhibition >8.5 pIC50 - 2
pIC50 >8.5 (IC50 <3x10-9 M) [2]
Janus kinase 2 Inhibitor Inhibition 8.1 pIC50 - 1
pIC50 8.1 (IC50 8x10-9 M) [1]
Janus kinase 3 Inhibitor Inhibition 5.4 pIC50 - 1
pIC50 5.4 (IC50 3.63x10-6 M) [1]