thiotepa

Ligand id: 7622

Name: thiotepa

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: thiotepa

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 50.93
Molecular weight 189.05
XLogP 0.76
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1959), EMA (2010))
IUPAC Name
tris(aziridin-1-yl)-sulfanylidenephosphorane
International Nonproprietary Names
INN number INN
881 thiotepa
Synonyms
Tepadina® | Thioplex®
Database Links
CAS Registry No. 52-24-4
ChEMBL Ligand CHEMBL671
DrugBank Ligand DB04572
GtoPdb PubChem SID 223365957
PubChem CID 5453
Search Google for chemical match using the InChIKey FOCVUCIESVLUNU-UHFFFAOYSA-N
Search Google for chemicals with the same backbone FOCVUCIESVLUNU
Search PubMed clinical trials thiotepa
Search PubMed titles thiotepa
Search PubMed titles/abstracts thiotepa
Search UniChem for chemical match using the InChIKey FOCVUCIESVLUNU-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone FOCVUCIESVLUNU
Wikipedia ThioTEPA
Comments
Thiotepa is an organophosphorus DNA alkylating anti-cancer chemotherapeutic [1].