inotuzumab ozogamicin

Ligand id: 8266

Name: inotuzumab ozogamicin

Classification
Compound class Antibody
Ligand families/groups Immune checkpoint modulators
Approved drug? Yes (EMA & FDA (2017))
International Nonproprietary Names
INN number INN
8574 inotuzumab ozogamicin
Synonyms
Besponsa® | CMC-544
Database Links
Specialist databases
IMGT/mAb-DB 259
Other databases
GtoPdb PubChem SID 252166478
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Wikipedia Inotuzumab ozogamicin
Comments
Inotuzumab ozogamicin is an antibody-drug conjugate (ADC) that targets delivery of the highly cytotoxic ozogamicin (a derivative of calicheamicin γ1) to CD22 (SIGLEC-2) +ve myeloid cells [1]. The calicheamicin derivative is N-acetyl gamma calicheamicin dimethylhydrazide as reported by DiJoseph et al (2004) [1].