L-Tyrosine hydroxylase

Target id: 1243

Nomenclature: L-Tyrosine hydroxylase

Family: Amino acid hydroxylases, Catecholamine turnover

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for L-Tyrosine hydroxylase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 528 11p15.5 TH tyrosine hydroxylase
Mouse - 498 7 88.06 cM Th tyrosine hydroxylase
Rat - 498 1q41 Th tyrosine hydroxylase
Previous and Unofficial Names
Tyrosine 3-monooxygenase | The | tyrosine 3-hydroxylase
Database Links
BRENDA
CATH/Gene3D
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.14.16.2 L-tyrosine + O2 -> levodopa
Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
L-tyrosine N/A - -
Products
Product Species Reference
levodopa None
Cofactors
Cofactor Species Comments Reference
sapropterin Human
Fe2+ Human
Endogenous activators
Protein kinase A-mediated phosphorylation  [1]

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
methyltyrosine Hs Inhibition - -
α-propyldopacetamide Hs Inhibition - -
3-chlorotyrosine Hs Inhibition - -
3-iodotyrosine Hs Inhibition - -
alpha-methyltyrosine Hs Inhibition - -
Clinically-Relevant Mutations and Pathophysiology
Disease:  Segawa syndrome, autosomal recessive
Synonyms: Autosomal recessive dopa-responsive dystonia [Orphanet: ORPHA101150]
OMIM: 605407
Orphanet: ORPHA101150

References

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1. Joh TH, Park DH, Reis DJ. (1978) Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: mechanism of enzyme activation. Proc. Natl. Acad. Sci. U.S.A.75 (10): 4744-8. [PMID:33381]

How to cite this page

Catecholamine turnover: L-Tyrosine hydroxylase . Last modified on 01/04/2015. Accessed on 21/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1243.