L-Aromatic amino-acid decarboxylase

Target id: 1271

Nomenclature: L-Aromatic amino-acid decarboxylase

Abbreviated Name: AADC

Family: Decarboxylases, Catecholamine turnover

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for L-Aromatic amino-acid decarboxylase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 480 7p12.1 DDC dopa decarboxylase
Mouse - 480 11 7.09 cM Ddc dopa decarboxylase
Rat - 480 14q21 Ddc dopa decarboxylase
Previous and Unofficial Names
5-hydroxytryptophan decarboxylase | DOPA decarboxylase | L-Dopa decarboxylase | dopa decarboxylase (aromatic L-amino acid decarboxylase)
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of Human aromatic L-amino acid decarboxylase (AADC) in the apo form
PDB Id:  3RBF
Resolution:  2.9Å
Species:  Human
References:  2
Enzyme Reaction
EC Number: 4.1.1.28 Levodopa -> dopamine + CO2
5-hydroxy-L-tryptophan -> 5-hydroxytryptamine + CO2
Description Reaction Reference
This enzyme also catalyses the following reaction: L-tryptophan -> tryptamine + CO2
Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
L-tryptophan Hs - -
levodopa Hs - -
5-hydroxy-L-tryptophan Hs - -
Deuterium-substituted L-DOPA Hs - - 3
Cofactors
Cofactor Species Comments Reference
pyridoxal phosphate None

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
3-hydroxybenzylhydrazine Hs Inhibition - -
benserazide Hs Inhibition - - 1
[1]
carbidopa Hs Inhibition - -
L-α-methyldopa Hs Inhibition - -
Clinically-Relevant Mutations and Pathophysiology
Disease:  Aromatic L-amino acid decarboxylase deficiency
OMIM: 608643
Orphanet: ORPHA35708

References

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1. Daidone F, Montioli R, Paiardini A, Cellini B, Macchiarulo A, Giardina G, Bossa F, Borri Voltattorni C. (2012) Identification by virtual screening and in vitro testing of human DOPA decarboxylase inhibitors. PLoS ONE7 (2): e31610. [PMID:22384042]

2. Giardina G, Montioli R, Gianni S, Cellini B, Paiardini A, Voltattorni CB, Cutruzzolà F. (2011) Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases. Proc. Natl. Acad. Sci. U.S.A.108 (51): 20514-9. [PMID:22143761]

3. Malmlöf T, Feltmann K, Konradsson-Geuken Å, Schneider F, Alken RG, Svensson TH, Schilström B. (2015) Deuterium-substituted L-DOPA displays increased behavioral potency and dopamine output in an animal model of Parkinson's disease: comparison with the effects produced by L-DOPA and an MAO-B inhibitor. J Neural Transm122 (2): 259-72. [PMID:24906468]

How to cite this page

Decarboxylases: L-Aromatic amino-acid decarboxylase . Last modified on 21/07/2015. Accessed on 11/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1271.