Top ▲
Target not currently curated in GtoImmuPdb
Target id: 1271
Nomenclature: L-Aromatic amino-acid decarboxylase
Abbreviated Name: AADC
Family: Decarboxylases, Catecholamine turnover
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 480 | 7p12.2-p12.1 | DDC | dopa decarboxylase | |
Mouse | - | 480 | 11 7.09 cM | Ddc | dopa decarboxylase | |
Rat | - | 480 | 14q21 | Ddc | dopa decarboxylase |
Previous and Unofficial Names |
5-hydroxytryptophan decarboxylase | DOPA decarboxylase | L-Dopa decarboxylase | dopa decarboxylase (aromatic L-amino acid decarboxylase) |
Database Links | |
Alphafold | P20711 (Hs), O88533 (Mm), P14173 (Rn) |
BRENDA | 4.1.1.28 |
CATH/Gene3D | 3.90.1150.10, 3.40.640.10 |
ChEMBL Target | CHEMBL1843 (Hs), CHEMBL4230 (Mm) |
DrugBank Target | P20711 (Hs) |
Ensembl Gene | ENSG00000132437 (Hs), ENSMUSG00000020182 (Mm), ENSRNOG00000004327 (Rn) |
Entrez Gene | 1644 (Hs), 13195 (Mm), 24311 (Rn) |
Human Protein Atlas | ENSG00000132437 (Hs) |
KEGG Enzyme | 4.1.1.28 |
KEGG Gene | hsa:1644 (Hs), mmu:13195 (Mm), rno:24311 (Rn) |
OMIM | 107930 (Hs) |
Orphanet | ORPHA121047 (Hs) |
Pharos | P20711 (Hs) |
UniProtKB | P20711 (Hs), O88533 (Mm), P14173 (Rn) |
Wikipedia | DDC (Hs) |
Selected 3D Structures | |||||||||||
|
Enzyme Reaction | ||||||||||
|
Substrates and Reaction Kinetics | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Cofactors | ||||||||
|
Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Clinically-Relevant Mutations and Pathophysiology | ||||||||||
|
1. Daidone F, Montioli R, Paiardini A, Cellini B, Macchiarulo A, Giardina G, Bossa F, Borri Voltattorni C. (2012) Identification by virtual screening and in vitro testing of human DOPA decarboxylase inhibitors. PLoS ONE, 7 (2): e31610. [PMID:22384042]
2. Giardina G, Montioli R, Gianni S, Cellini B, Paiardini A, Voltattorni CB, Cutruzzolà F. (2011) Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases. Proc Natl Acad Sci USA, 108 (51): 20514-9. [PMID:22143761]
3. Malmlöf T, Feltmann K, Konradsson-Geuken Å, Schneider F, Alken RG, Svensson TH, Schilström B. (2015) Deuterium-substituted L-DOPA displays increased behavioral potency and dopamine output in an animal model of Parkinson's disease: comparison with the effects produced by L-DOPA and an MAO-B inhibitor. J Neural Transm, 122 (2): 259-72. [PMID:24906468]
Decarboxylases: L-Aromatic amino-acid decarboxylase . Last modified on 10/07/2018. Accessed on 07/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1271.