Target id: 1359

Nomenclature: CYP11B1

Family: CYP11, CYP17, CYP19, CYP20 and CYP21 families

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for CYP11B1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 503 8q21-q22 CYP11B1 cytochrome P450 family 11 subfamily B member 1
Mouse - 501 15 34.29 cM Cyp11b1 cytochrome P450
Rat - 499 7q34 Cyp11b1 cytochrome P450
Previous and Unofficial Names
cytochrome P450, subfamily XIB, polypeptide 1 | cytochrome P450 11B1, mitochondrial | steroid 11-beta-hydroxylase | cytochrome P450, family 11, subfamily B, polypeptide 1 | cytochrome P450, family 11, subfamily b, polypeptide 1 | cytochrome P450
Database Links
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
fadrozole Hs Inhibition 8.7 pKi 1
pKi 8.7 (Ki 2.2x10-9 M) [1]
azalanstat Bt Inhibition 7.5 pKi 3
pKi 7.5 (Ki 3.5x10-8 M) [3]
osilodrostat Hs Inhibition 8.5 pIC50 4
pIC50 8.5 (IC50 2.9x10-9 M) [4]
metyrapone Hs Inhibition 7.8 pIC50 5
pIC50 7.8 (IC50 1.46x10-8 M) [5]
mitotane Hs Inhibition - -
View species-specific inhibitor tables
Clinically-Relevant Mutations and Pathophysiology
Disease:  Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency
Synonyms: Congenital adrenal hyperplasia [Disease Ontology: DOID:12255]
Disease Ontology: DOID:12255
OMIM: 202010
Orphanet: ORPHA90795
References:  2
Disease:  Familial hyperaldosteronism type I
Synonyms: Glucocorticoid-remediable aldosteronism; GRA [OMIM: 103900]
OMIM: 103900
Orphanet: ORPHA403


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1. LaSala D, Shibanaka Y, Jeng AY. (2009) Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors. Anal. Biochem.394 (1): 56-61. [PMID:19622340]

2. No authors listed. (2004) Natalizumab: AN 100226, anti-4alpha integrin monoclonal antibody. Drugs R D5 (2): 102-7. [PMID:15293871]

3. Walker KA, Kertesz DJ, Rotstein DM, Swinney DC, Berry PW, So OY, Webb AS, Watson DM, Mak AY, Burton PM et al.. (1993) Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. J. Med. Chem.36 (15): 2235-7. [PMID:8340925]

4. Yin L, Hu Q, Emmerich J, Lo MM, Metzger E, Ali A, Hartmann RW. (2014) Novel pyridyl- or isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone synthase inhibitors. J. Med. Chem.57 (12): 5179-89. [PMID:24899257]

5. Zimmer C, Hafner M, Zender M, Ammann D, Hartmann RW, Vock CA. (2011) N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2). Bioorg. Med. Chem. Lett.21 (1): 186-90. [PMID:21129965]

How to cite this page

CYP11, CYP17, CYP19, CYP20 and CYP21 families: CYP11B1. Last modified on 22/10/2015. Accessed on 19/02/2018. IUPHAR/BPS Guide to PHARMACOLOGY,