CYP11B1

Target id: 1359

Nomenclature: CYP11B1

Family: CYP11, CYP17, CYP19, CYP20 and CYP21 families

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for CYP11B1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 503 8q21-q22 CYP11B1 cytochrome P450 family 11 subfamily B member 1
Mouse - 501 15 34.29 cM Cyp11b1 cytochrome P450
Rat - 499 7q34 Cyp11b1 cytochrome P450
Previous and Unofficial Names
cytochrome P450, subfamily XIB, polypeptide 1 | cytochrome P450 11B1, mitochondrial | steroid 11-beta-hydroxylase | cytochrome P450, family 11, subfamily B, polypeptide 1 | cytochrome P450, family 11, subfamily b, polypeptide 1 | cytochrome P450
Database Links
BRENDA
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.14.15.4

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
fadrozole Hs Inhibition 8.7 pKi 1
pKi 8.7 (Ki 2.2x10-9 M) [1]
azalanstat Bt Inhibition 7.5 pKi 3
pKi 7.5 (Ki 3.5x10-8 M) [3]
osilodrostat Hs Inhibition 8.5 pIC50 4
pIC50 8.5 (IC50 2.9x10-9 M) [4]
metyrapone Hs Inhibition 7.8 pIC50 5
pIC50 7.8 (IC50 1.46x10-8 M) [5]
mitotane Hs Inhibition - -
View species-specific inhibitor tables
Clinically-Relevant Mutations and Pathophysiology
Disease:  Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency
Synonyms: Congenital adrenal hyperplasia [Disease Ontology: DOID:12255]
Disease Ontology: DOID:12255
OMIM: 202010
Orphanet: ORPHA90795
References:  2
Disease:  Familial hyperaldosteronism type I
Synonyms: Glucocorticoid-remediable aldosteronism; GRA [OMIM: 103900]
OMIM: 103900
Orphanet: ORPHA403

References

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1. LaSala D, Shibanaka Y, Jeng AY. (2009) Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors. Anal. Biochem.394 (1): 56-61. [PMID:19622340]

2. No authors listed. (2004) Natalizumab: AN 100226, anti-4alpha integrin monoclonal antibody. Drugs R D5 (2): 102-7. [PMID:15293871]

3. Walker KA, Kertesz DJ, Rotstein DM, Swinney DC, Berry PW, So OY, Webb AS, Watson DM, Mak AY, Burton PM et al.. (1993) Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. J. Med. Chem.36 (15): 2235-7. [PMID:8340925]

4. Yin L, Hu Q, Emmerich J, Lo MM, Metzger E, Ali A, Hartmann RW. (2014) Novel pyridyl- or isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone synthase inhibitors. J. Med. Chem.57 (12): 5179-89. [PMID:24899257]

5. Zimmer C, Hafner M, Zender M, Ammann D, Hartmann RW, Vock CA. (2011) N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2). Bioorg. Med. Chem. Lett.21 (1): 186-90. [PMID:21129965]

How to cite this page

CYP11, CYP17, CYP19, CYP20 and CYP21 families: CYP11B1. Last modified on 22/10/2015. Accessed on 11/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1359.