CYP11B2 | CYP11, CYP17, CYP19, CYP20 and CYP21 families | IUPHAR/BPS Guide to PHARMACOLOGY


Target id: 1360

Nomenclature: CYP11B2

Abbreviated Name: Aldosterone synthase

Family: CYP11, CYP17, CYP19, CYP20 and CYP21 families

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for CYP11B2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - CYP11B2 cytochrome P450 family 11 subfamily B member 2
Mouse - - Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2
Rat - - Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2
Previous and Unofficial Names
ALDOS | aldosterone-synthesizing enzyme | cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2 | cytochrome P450 11B2, mitochondrial | Cytochrome P450 subfamily XIB polypeptide 2 (aldosterone synthase) | cytochrome P450, family 11, subfamily b, polypeptide 2 | cytochrome P450
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
Enzyme Reaction
EC Number:
EC Number:

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
fadrozole Hs Inhibition 9.1 pKi 1
pKi 9.1 (Ki 8x10-10 M) [1]
osilodrostat Hs Inhibition 9.7 pIC50 2
pIC50 9.7 (IC50 2x10-10 M) [2]


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1. LaSala D, Shibanaka Y, Jeng AY. (2009) Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors. Anal. Biochem., 394 (1): 56-61. [PMID:19622340]

2. Yin L, Hu Q, Emmerich J, Lo MM, Metzger E, Ali A, Hartmann RW. (2014) Novel pyridyl- or isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone synthase inhibitors. J. Med. Chem., 57 (12): 5179-89. [PMID:24899257]

How to cite this page

CYP11, CYP17, CYP19, CYP20 and CYP21 families: CYP11B2. Last modified on 14/04/2015. Accessed on 18/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY,