Target id: 1360

Nomenclature: CYP11B2

Abbreviated Name: Aldosterone synthase

Family: CYP11, CYP17, CYP19, CYP20 and CYP21 families

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for CYP11B2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - CYP11B2 cytochrome P450 family 11 subfamily B member 2
Mouse - - Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2
Rat - - Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2
Previous and Unofficial Names
ALDOS | aldosterone-synthesizing enzyme | cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2 | cytochrome P450 11B2, mitochondrial | Cytochrome P450 subfamily XIB polypeptide 2 (aldosterone synthase) | cytochrome P450, family 11, subfamily b, polypeptide 2 | cytochrome P450
Database Links
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
Enzyme Reaction
EC Number:
EC Number:

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
fadrozole Hs Inhibition 9.1 pKi 1
pKi 9.1 (Ki 8x10-10 M) [1]
osilodrostat Hs Inhibition 9.7 pIC50 2
pIC50 9.7 (IC50 2x10-10 M) [2]


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1. LaSala D, Shibanaka Y, Jeng AY. (2009) Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors. Anal. Biochem.394 (1): 56-61. [PMID:19622340]

2. Yin L, Hu Q, Emmerich J, Lo MM, Metzger E, Ali A, Hartmann RW. (2014) Novel pyridyl- or isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone synthase inhibitors. J. Med. Chem.57 (12): 5179-89. [PMID:24899257]

How to cite this page

CYP11, CYP17, CYP19, CYP20 and CYP21 families: CYP11B2. Last modified on 14/04/2015. Accessed on 18/03/2018. IUPHAR/BPS Guide to PHARMACOLOGY,