5-LOX

Target id: 1385

Nomenclature: 5-LOX

Family: Lipoxygenases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     5-LOX has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 674 10q11.2 ALOX5 arachidonate 5-lipoxygenase
Mouse - 674 6 53.79 cM Alox5 arachidonate 5-lipoxygenase
Rat - 673 4q42 Alox5 arachidonate 5-lipoxygenase
Previous and Unofficial Names
ALOX5 | 5-lipoxygenase | 5-LO | arachidonate 5-lipoxygenase
Database Links
BRENDA
CATH/Gene3D
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.13.11.34 Arachidonic acid + O2 = LTA4 + H2O
Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
arachidonic acid Hs - -
Endogenous inhibitor
Protein kinase A-mediated phosphorylation  [2]

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Activators
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
5-LOX activating protein {Sp: Human} Hs Activation - -
Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
CJ13610 Hs Inhibition 7.2 pIC50 1
pIC50 7.2 (IC50 7x10-8 M) [1]
PF-04191834 Hs Inhibition 6.6 pIC50 3
pIC50 6.6 (IC50 2.29x10-7 M) [3]
zileuton Hs Inhibition - -
Immunopharmacology Comments
5LOX is included in GtoImmuPdb because of its involvement in eicosanoid turnover.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  leukotriene production involved in inflammatory response (GO:0002540) IEA
neutrophil degranulation (GO:0043312) TAS
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  neutrophil degranulation (GO:0043312) TAS
References: 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Asthma, susceptibility to
Disease Ontology: DOID:2841
OMIM: 600807
Role: 

References

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1. Fischer L, Steinhilber D, Werz O. (2004) Molecular pharmacological profile of the nonredox-type 5-lipoxygenase inhibitor CJ-13,610. Br. J. Pharmacol.142 (5): 861-8. [PMID:15197110]

2. Luo M, Jones SM, Phare SM, Coffey MJ, Peters-Golden M, Brock TG. (2004) Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523. J. Biol. Chem.279 (40): 41512-20. [PMID:15280375]

3. Masferrer JL, Zweifel BS, Hardy M, Anderson GD, Dufield D, Cortes-Burgos L, Pufahl RA, Graneto M. (2010) Pharmacology of PF-4191834, a novel, selective non-redox 5-lipoxygenase inhibitor effective in inflammation and pain. J. Pharmacol. Exp. Ther.334 (1): 294-301. [PMID:20378715]

How to cite this page

Lipoxygenases: 5-LOX. Last modified on 22/02/2017. Accessed on 14/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1385.