MMP8

Target id: 1632

Nomenclature: MMP8

Family: M10: Matrix metallopeptidase

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     MMP8 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 467 11q21-q22 MMP8 matrix metallopeptidase 8
Mouse - 465 9 A1 Mmp8 matrix metallopeptidase 8
Rat - 466 8q11 Mmp8 matrix metallopeptidase 8
Previous and Unofficial Names
PMNL collagenase | neutrophil collagenease | Collagenase-2 | CLG1 | matrix metallopeptidase 8 (neutrophil collagenase)
Database Links
Specialist databases
MEROPS M10.002 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.24.34

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
SL422 Hs Inhibition 9.3 pKi 4
pKi 9.3 (Ki 5x10-10 M) [4]
ONO-4817 Hs Inhibition 9.0 pKi 5
pKi 9.0 (Ki 1.1x10-9 M) [5]
CGS-27023A Hs Inhibition 8.1 pIC50 2
pIC50 8.1 (IC50 7.7x10-9 M) [2]
doxycycline Hs Inhibition 4.6 pIC50 3
pIC50 4.6 (IC50 2.6x10-5 M) [3]
Inhibitor Comments
SL422 is a broad-spectrum inhibitor of MMP enzymes [4].
Immunopharmacology Comments
MMP8 is included in GtoImmuPdb based on its potential protective role in asthma.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS
Immuno Disease Associations
Disease Name:  Asthma
Disease Synonyms:  no synonynms
Comment:  MMP8 plays a protective role in asthma by promoting the clearance of recruited neutrophils.
Disease X-refs:  Disease Ontology: DOID:2841
OMIM: 600807
References:  1

References

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1. Gueders MM, Balbin M, Rocks N, Foidart JM, Gosset P, Louis R, Shapiro S, Lopez-Otin C, Noël A, Cataldo DD. (2005) Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation. J. Immunol., 175 (4): 2589-97. [PMID:16081833]

2. Nuti E, Casalini F, Santamaria S, Gabelloni P, Bendinelli S, Da Pozzo E, Costa B, Marinelli L, La Pietra V, Novellino E et al.. (2011) Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors. Eur J Med Chem, 46 (7): 2617-29. [PMID:21514700]

3. Sepper R, Konttinen YT, Ding Y, Takagi M, Sorsa T. (1995) Human neutrophil collagenase (MMP-8), identified in bronchiectasis BAL fluid, correlates with severity of disease. Chest, 107 (6): 1641-7. [PMID:7781360]

4. Xue CB, Voss ME, Nelson DJ, Duan JJ, Cherney RJ, Jacobson IC, He X, Roderick J, Chen L, Corbett RL et al.. (2001) Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. J. Med. Chem., 44 (16): 2636-60. [PMID:11472217]

5. Yamada A, Uegaki A, Nakamura T, Ogawa K. (2000) ONO-4817, an orally active matrix metalloproteinase inhibitor, prevents lipopolysaccharide-induced proteoglycan release from the joint cartilage in guinea pigs. Inflamm. Res., 49 (4): 144-6. [PMID:10858013]

How to cite this page

M10: Matrix metallopeptidase: MMP8. Last modified on 19/04/2017. Accessed on 22/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1632.