Eythropoietin receptor

Target id: 1718

Nomenclature: Eythropoietin receptor

Family: Prolactin receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Eythropoietin receptor in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 508 19p13.3-p13.2 EPOR erythropoietin receptor
Mouse 1 507 9 7.93 cM Epor erythropoietin receptor
Rat 1 507 8q13 Epor erythropoietin receptor
Previous and Unofficial Names
EPO-R | erythropoietin receptor
Database Links
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of human erythropoietin complexed to its receptor at 1.9 angstroms
Ligand:  erythropoietin
Resolution:  1.9Å
Species:  Human
References:  2

Download all structure-activity data for this target as a CSV file

Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
erythropoietin {Sp: Human} Hs Agonist 11.1 pIC50 1
pIC50 11.1 (IC50 7x10-12 M) [1]
Description: Assay performed using recombinant human EPO
peginesatide Hs Agonist 10.4 pIC50 1
pIC50 10.4 (IC50 3.7x10-11 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Erythrocytosis, familial, 1; ECYT1
Synonyms: Primary familial polycythemia [Orphanet: ORPHA90042]
OMIM: 133100
Orphanet: ORPHA90042


Show »

1. Fan Q, Leuther KK, Holmes CP, Fong KL, Zhang J, Velkovska S, Chen MJ, Mortensen RB, Leu K, Green JM et al.. (2006) Preclinical evaluation of Hematide, a novel erythropoiesis stimulating agent, for the treatment of anemia. Exp. Hematol.34 (10): 1303-11. [PMID:16982323]

2. Syed RS, Reid SW, Li C, Cheetham JC, Aoki KH, Liu B, Zhan H, Osslund TD, Chirino AJ, Zhang J et al.. (1998) Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature395 (6701): 511-6. [PMID:9774108]

How to cite this page

Prolactin receptor family: Eythropoietin receptor. Last modified on 22/05/2014. Accessed on 22/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1718.