Eythropoietin receptor

Target id: 1718

Nomenclature: Eythropoietin receptor

Family: Prolactin receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Eythropoietin receptor in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 508 19p13.3-p13.2 EPOR erythropoietin receptor
Mouse 1 507 9 7.93 cM Epor erythropoietin receptor
Rat 1 507 8q13 Epor erythropoietin receptor
Previous and Unofficial Names
EPO-R | erythropoietin receptor
Database Links
CATH/Gene3D
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
Orphanet
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of human erythropoietin complexed to its receptor at 1.9 angstroms
PDB Id:  1EER
Ligand:  erythropoietin
Resolution:  1.9Å
Species:  Human
References:  2

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Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
erythropoietin {Sp: Human} Hs Agonist 11.1 pIC50 1
pIC50 11.1 (IC50 7x10-12 M) [1]
Description: Assay performed using recombinant human EPO
peginesatide Hs Agonist 10.4 pIC50 1
pIC50 10.4 (IC50 3.7x10-11 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Erythrocytosis, familial, 1; ECYT1
Synonyms: Primary familial polycythemia [Orphanet: ORPHA90042]
OMIM: 133100
Orphanet: ORPHA90042

References

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1. Fan Q, Leuther KK, Holmes CP, Fong KL, Zhang J, Velkovska S, Chen MJ, Mortensen RB, Leu K, Green JM et al.. (2006) Preclinical evaluation of Hematide, a novel erythropoiesis stimulating agent, for the treatment of anemia. Exp. Hematol.34 (10): 1303-11. [PMID:16982323]

2. Syed RS, Reid SW, Li C, Cheetham JC, Aoki KH, Liu B, Zhan H, Osslund TD, Chirino AJ, Zhang J et al.. (1998) Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature395 (6701): 511-6. [PMID:9774108]

How to cite this page

Prolactin receptor family: Eythropoietin receptor. Last modified on 22/05/2014. Accessed on 22/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1718.