Thrombopoietin receptor

Target id: 1722

Nomenclature: Thrombopoietin receptor

Family: Prolactin receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Thrombopoietin receptor in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 635 1p34 MPL MPL proto-oncogene, thrombopoietin receptor
Mouse - 625 4 54.61 cM Mpl myeloproliferative leukemia virus oncogene
Rat - - 5q36 Mpl MPL proto-oncogene, thrombopoietin receptor
Previous and Unofficial Names
CD110 | MPL | Myeloproliferative leukemia protein | TPOR | MPL proto-oncogene, thrombopoietin receptor | MPL proto-oncogene
Database Links
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
eltrombopag Hs Agonist 7.4 pEC50 2
pEC50 7.4 (EC50 3.8x10-8 M) [2]
thrombopoietin {Sp: Human} Hs Agonist - -
romiplostim Hs Agonist - -
avatrombopag Hs Agonist - - 1
Clinically-Relevant Mutations and Pathophysiology
Disease:  Congenital amegakaryocytic thrombocytopenia
OMIM: 604498
Orphanet: ORPHA3319
Disease:  Familial thrombocytosis
Description: A rare chronic myeloproliferative neoplasm (MPN) causing overproduction of platelets.
Synonyms: essential thrombocythaemia
hemorrhagic thrombocythemia
hereditary thrombocythemia
primary thrombocytosis
Disease Ontology: DOID:2224
Orphanet: ORPHA71493
Disease:  Myelofibrosis
Synonyms: Myelofibrosis with myeloid metaplasia [Orphanet: ORPHA824]
Disease Ontology: DOID:4971
OMIM: 254450
Orphanet: ORPHA824
Disease:  Polycythemia vera
Disease Ontology: DOID:8997
OMIM: 263300
Orphanet: ORPHA729
Disease:  Thrombocythemia 2; THCYT2
Synonyms: Essential thrombocythemia [Orphanet: ORPHA3318]
Essential thrombocytosis [Orphanet: ORPHA3318]
OMIM: 601977
Orphanet: ORPHA3318


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1. Fukushima-Shintani M, Suzuki K, Iwatsuki Y, Abe M, Sugasawa K, Hirayama F, Kawasaki T, Nakahata T. (2009) AKR-501 (YM477) a novel orally-active thrombopoietin receptor agonist. Eur. J. Haematol., 82 (4): 247-54. [PMID:19183407]

2. Marsilje TH, Alper PB, Lu W, Mutnick D, Michellys PY, He Y, Karanewsky DS, Chow D, Gerken A, Lao J et al.. (2008) Optimization of small molecule agonists of the thrombopoietin (Tpo) receptor derived from a benzo[a]carbazole hit scaffold. Bioorg. Med. Chem. Lett., 18 (19): 5259-62. [PMID:18783949]

How to cite this page

Prolactin receptor family: Thrombopoietin receptor. Last modified on 22/05/2018. Accessed on 17/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY,