NLRC3 | NOD-like receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

NLRC3

Target id: 1764

Nomenclature: NLRC3

Family: NOD-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     NLRC3 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1065 16p13.3 NLRC3 NLR family CARD domain containing 3
Mouse - 1064 16 2.32 cM Nlrc3 NLR family, CARD domain containing 3
Rat - - 10 q12 Nlrc3 NLR family, CARD domain containing 3
Previous and Unofficial Names
CLR16.2 | nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3 | NLR family, CARD domain containing 3 | Caterpiller 16.2 | NOD3 | NLR family
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
UniProtKB
Wikipedia
Immunopharmacology Comments
NLRC3 is an intracellular pattern recognition receptor of the innate immune system. It has been shown to directly interact with and inhibit the type I interferon response of the intracellular DNA sensor STING to cytosolic DNA, cyclic di-GMP (c-di-GMP), and DNA viruses [1-2].
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0045824 negative regulation of innate immune response ISS
GO:0050728 negative regulation of inflammatory response IDA
GO:1900016 negative regulation of cytokine production involved in inflammatory response ISS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0042110 T cell activation IEP
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0045824 negative regulation of innate immune response ISS
GO:0050728 negative regulation of inflammatory response IDA
GO:1900016 negative regulation of cytokine production involved in inflammatory response ISS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 5 GO processes
GO:0032687 negative regulation of interferon-alpha production ISS
GO:0032688 negative regulation of interferon-beta production ISS
GO:0032715 negative regulation of interleukin-6 production IDA
GO:0032720 negative regulation of tumor necrosis factor production IDA
GO:1900016 negative regulation of cytokine production involved in inflammatory response ISS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0042110 T cell activation IEP
Physiological Functions Comments
Negative regulation of inflammatory signalling.

References

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1. Mangan MS, Latz E. (2014) NLRC3 puts the brakes on STING. Immunity, 40 (3): 305-6. [PMID:24656040]

2. Zhang L, Mo J, Swanson KV, Wen H, Petrucelli A, Gregory SM, Zhang Z, Schneider M, Jiang Y, Fitzgerald KA et al.. (2014) NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING. Immunity, 40 (3): 329-41. [PMID:24560620]

Contributors

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How to cite this page

Clare Bryant, Tom Monie.
NOD-like receptor family: NLRC3. Last modified on 13/04/2018. Accessed on 14/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1764.