NLRC5 | NOD-like receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

NLRC5

Target id: 1765

Nomenclature: NLRC5

Family: NOD-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     NLRC5 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1866 16q13 NLRC5 NLR family CARD domain containing 5
Mouse - 1915 8 46.55 cM Nlrc5 NLR family, CARD domain containing 5
Previous and Unofficial Names
CLR16.1 | NOD27 | NOD4 | NOD-like receptor C5 | nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5 | NLR family, CARD domain containing 5 | NLR family
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
NLRC5 is an intracellular pattern recognition receptor mediating an innate immune response to viral infection [4], likely by modulating the NF-κB and type I interferon signaling pathways [1-2].
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 4 GO processes
GO:0045087 innate immune response IMP
GO:0060335 positive regulation of interferon-gamma-mediated signaling pathway IDA
GO:0060339 negative regulation of type I interferon-mediated signaling pathway IDA
GO:0060340 positive regulation of type I interferon-mediated signaling pathway IDA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0060335 positive regulation of interferon-gamma-mediated signaling pathway IDA
GO:0060339 negative regulation of type I interferon-mediated signaling pathway IDA
GO:0060340 positive regulation of type I interferon-mediated signaling pathway IDA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 4 GO processes
GO:0032480 negative regulation of type I interferon production TAS
GO:0060335 positive regulation of interferon-gamma-mediated signaling pathway IDA
GO:0060339 negative regulation of type I interferon-mediated signaling pathway IDA
GO:0060340 positive regulation of type I interferon-mediated signaling pathway IDA
Immuno Disease Associations
Disease Name:  Rheumatoid arthritis
Disease Synonyms:  no synonynms
Comment:  A study by Liu et al. (2017) found that NLRC5 is upregulated in synovial tissues and cells of AA animal models, NLRC5 silencing inhibits inflammatory cytokine expression and cell proliferation of fibroblast-like synoviocytes, and that NLRC5 expression inducescell proliferation via NF-κB activation and signaling.
Disease X-refs:  Disease Ontology: DOID:7148
OMIM: 180300
References:  3
Physiological Functions Comments
Transactivator of class I major histocompatibility complex genes.

References

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1. Cui J, Zhu L, Xia X, Wang HY, Legras X, Hong J, Ji J, Shen P, Zheng S, Chen ZJ et al.. (2010) NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell, 141 (3): 483-96. [PMID:20434986]

2. Kuenzel S, Till A, Winkler M, Häsler R, Lipinski S, Jung S, Grötzinger J, Fickenscher H, Schreiber S, Rosenstiel P. (2010) The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses. J. Immunol., 184 (4): 1990-2000. [PMID:20061403]

3. Liu YR, Yan X, Yu HX, Yao Y, Wang JQ, Li XF, Chen RN, Xu QQ, Ma TT, Huang C et al.. (2017) NLRC5 promotes cell proliferation via regulating the NF-κB signaling pathway in Rheumatoid arthritis. Mol. Immunol., 91: 24-34. [PMID:28865311]

4. Neerincx A, Lautz K, Menning M, Kremmer E, Zigrino P, Hösel M, Büning H, Schwarzenbacher R, Kufer TA. (2010) A role for the human nucleotide-binding domain, leucine-rich repeat-containing family member NLRC5 in antiviral responses. J. Biol. Chem., 285 (34): 26223-32. [PMID:20538593]

Contributors

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How to cite this page

Clare Bryant, Tom Monie.
NOD-like receptor family: NLRC5. Last modified on 29/09/2017. Accessed on 17/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1765.