NLRX1 | NOD-like receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

NLRX1

Target id: 1766

Nomenclature: NLRX1

Family: NOD-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     NLRX1 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 889 11q23.3 NLRX1 NLR family member X1
Mouse - 889 9 24.84 cM Nlrx1 NLR family member X1
Rat - 889 8q22 Nlrx1 NLR family member X1
Previous and Unofficial Names
CLR11.3 | NOD9 | NOD-like receptor X1 | NLR family member X1 | DLNB26 | NOD26 | NOD5
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
NLRX1 is an intracellular pattern recognition receptor that plays a role in host immunity to certain bacterial infections.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 4 GO processes
GO:0032480 negative regulation of type I interferon production TAS
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GO:0032688 negative regulation of interferon-beta production IEA
GO:0032715 negative regulation of interleukin-6 production IEA
GO:0039536 negative regulation of RIG-I signaling pathway IEA
Immuno Process:  Inflammation
GO Annotations:  Associated to 4 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0039536 negative regulation of RIG-I signaling pathway IEA
GO:0045087 innate immune response IEA
GO:0045824 negative regulation of innate immune response IEA
GO:0050728 negative regulation of inflammatory response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0039536 negative regulation of RIG-I signaling pathway IEA
GO:0045824 negative regulation of innate immune response IEA
GO:0050728 negative regulation of inflammatory response IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0039536 negative regulation of RIG-I signaling pathway IEA
Physiological Functions Comments
Involved in negative regulation of inflammatory signalling.

Contributors

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How to cite this page

Clare Bryant, Tom Monie.
NOD-like receptor family: NLRX1. Last modified on 22/03/2017. Accessed on 13/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1766.