NLRP10 | NOD-like receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

NLRP10

Target id: 1777

Nomenclature: NLRP10

Family: NOD-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     NLRP10 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 655 11p15.4 NLRP10 NLR family pyrin domain containing 10
Mouse - 673 7 57.21 cM Nlrp10 NLR family, pyrin domain containing 10
Rat - - 1q33 Nlrp10 NLR family, pyrin domain containing 10
Previous and Unofficial Names
NALP10 | NOD8 | PAN5 | Pynod | NACHT, leucine rich repeat and PYD containing 10 | NLR family, pyrin domain containing 10 | CLR11.1 | NLR family
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
NLRP10 is an intracellular pattern recognition receptor (PRR) that has apoptotic and anti-inflammatory functions [1]. Unlike other other NOD-like receptors, NLRP10 is missing the characteristic leucine-rich repeat domain.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 4 GO processes
GO:0036336 dendritic cell migration ISS
GO:0050729 positive regulation of inflammatory response ISS
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GO:0006954 inflammatory response IEA
GO:0045087 innate immune response IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 4 GO processes
GO:0002827 positive regulation of T-helper 1 type immune response ISS
GO:0035397 helper T cell enhancement of adaptive immune response ISS
GO:2000318 positive regulation of T-helper 17 type immune response ISS
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GO:0002250 adaptive immune response IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 4 GO processes
GO:0002827 positive regulation of T-helper 1 type immune response ISS
GO:0035397 helper T cell enhancement of adaptive immune response ISS
GO:2000318 positive regulation of T-helper 17 type immune response ISS
click arrow to show/hide IEA associations
GO:0002250 adaptive immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 4 GO processes
GO:0002827 positive regulation of T-helper 1 type immune response ISS
GO:0035397 helper T cell enhancement of adaptive immune response ISS
GO:0050729 positive regulation of inflammatory response ISS
GO:2000318 positive regulation of T-helper 17 type immune response ISS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes
GO:0050717 positive regulation of interleukin-1 alpha secretion IMP
GO:2000484 positive regulation of interleukin-8 secretion IMP
GO:2000778 positive regulation of interleukin-6 secretion IMP
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0036336 dendritic cell migration ISS
Physiological Functions Comments
Involved in antigen-presenting cell migration, T-Cell priming and NOD1 signalling enhancement.

References

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1. Imamura R, Wang Y, Kinoshita T, Suzuki M, Noda T, Sagara J, Taniguchi S, Okamoto H, Suda T. (2010) Anti-inflammatory activity of PYNOD and its mechanism in humans and mice. J. Immunol., 184 (10): 5874-84. [PMID:20393137]

Contributors

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How to cite this page

Clare Bryant, Tom Monie.
NOD-like receptor family: NLRP10. Last modified on 22/03/2017. Accessed on 15/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1777.