NLRP13 | NOD-like receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

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NLRP13

target has curated data in GtoImmuPdb

Target id: 1780

Nomenclature: NLRP13

Family: NOD-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1043 19q13.43 NLRP13 NLR family pyrin domain containing 13
Previous and Unofficial Names
CLR19.7 | NALP13 | NOD14 | PAN13 | NACHT, leucine rich repeat and PYD containing 13 | NLR family, pyrin domain containing 13
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
NLRP proteins are critical components of inflammasome complexes and are thereby involved in inflammasome-mediated activation of proinflammatory caspases. NLRP13 has the typical PYD-NACHT-LRR domain structure common to the NLRP protein family [1]. But despite this structural homology the biological function of NLRP13 is not as well defined as other related proteins.
General Comments
The function of NLRP13 is not well defined.

References

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1. Tschopp J, Martinon F, Burns K. (2003) NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol., 4 (2): 95-104. [PMID:12563287]

Contributors

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How to cite this page

Clare Bryant, Tom P. Monie.
NOD-like receptor family: NLRP13. Last modified on 17/10/2018. Accessed on 24/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1780.