NLRP14 | NOD-like receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

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NLRP14

target has curated data in GtoImmuPdb

Target id: 1781

Nomenclature: NLRP14

Family: NOD-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1093 11p15.4 NLRP14 NLR family pyrin domain containing 14
Mouse - 993 7 56.10 cM Nlrp14 NLR family
Previous and Unofficial Names
CLR11.2 | GC-LRR | NALP14 | NOD5 | PAN8 | NACHT, leucine rich repeat and PYD containing 14 | NLR family, pyrin domain containing 14 | NLR family
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
NLRP proteins are critical components of inflammasome complexes and are thereby involved in inflammasome-mediated activation of proinflammatory caspases. NLRP14 has the typical PYD-NACHT-LRR domain structure common to the NLRP protein family [1]. But despite this structural homology the biological function of NLRP14 is not as well defined as other similar proteins.
Tissue Distribution
NLRP14 is found exclusively in the testes: specifically expressed in spermatogonia, spermatocytes and spermatids
Species:  Human
Technique:  Northern blot, immunohistochemistry.
References:  2
Physiological Functions
Spermatogenesis
Species:  Human
Tissue:  Spermatogonia, spermatocytes and spermatids.
References:  2
Physiological Functions Comments
Involved in spermatogenesis
Clinically-Relevant Mutations and Pathophysiology
Disease:  Spermatogenic failure
Description: A common cause of male subfertility (see PubMed ID 10522977). Resulting from various etiologies.
Click column headers to sort
Type Species Amino acid change Nucleotide change Description Reference
Missense- premature STOP codon Human K108X Results in expression of a truncated protein which lacks the functional NACHT and LRR domains. 2

References

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1. Tschopp J, Martinon F, Burns K. (2003) NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol., 4 (2): 95-104. [PMID:12563287]

2. Westerveld GH, Korver CM, van Pelt AM, Leschot NJ, van der Veen F, Repping S, Lombardi MP. (2006) Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure. Hum. Reprod., 21 (12): 3178-84. [PMID:16931801]

Contributors

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How to cite this page

Clare Bryant, Tom P. Monie.
NOD-like receptor family: NLRP14. Last modified on 17/10/2018. Accessed on 19/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1781.