NLRP14 | NOD-like receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

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target has curated data in GtoImmuPdb

Target id: 1781

Nomenclature: NLRP14

Family: NOD-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1093 11p15.4 NLRP14 NLR family pyrin domain containing 14
Mouse - 993 7 56.10 cM Nlrp14 NLR family
Previous and Unofficial Names
CLR11.2 | GC-LRR | NALP14 | NOD5 | PAN8 | NACHT, leucine rich repeat and PYD containing 14 | NLR family, pyrin domain containing 14 | NLR family
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
Immunopharmacology Comments
NLRP proteins are critical components of inflammasome complexes and are thereby involved in inflammasome-mediated activation of proinflammatory caspases. NLRP14 has the typical PYD-NACHT-LRR domain structure common to the NLRP protein family [1]. But despite this structural homology the biological function of NLRP14 is not as well defined as other similar proteins.
Tissue Distribution
NLRP14 is found exclusively in the testes: specifically expressed in spermatogonia, spermatocytes and spermatids
Species:  Human
Technique:  Northern blot, immunohistochemistry.
References:  2
Physiological Functions
Species:  Human
Tissue:  Spermatogonia, spermatocytes and spermatids.
References:  2
Physiological Functions Comments
Involved in spermatogenesis
Clinically-Relevant Mutations and Pathophysiology
Disease:  Spermatogenic failure
Description: A common cause of male subfertility (see PubMed ID 10522977). Resulting from various etiologies.
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Type Species Amino acid change Nucleotide change Description Reference
Missense- premature STOP codon Human K108X Results in expression of a truncated protein which lacks the functional NACHT and LRR domains. 2


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1. Tschopp J, Martinon F, Burns K. (2003) NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol., 4 (2): 95-104. [PMID:12563287]

2. Westerveld GH, Korver CM, van Pelt AM, Leschot NJ, van der Veen F, Repping S, Lombardi MP. (2006) Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure. Hum. Reprod., 21 (12): 3178-84. [PMID:16931801]


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How to cite this page

Clare Bryant, Tom P. Monie.
NOD-like receptor family: NLRP14. Last modified on 17/10/2018. Accessed on 19/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY,