CD30 | Tumour necrosis factor (TNF) receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

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CD30

target has curated data in GtoImmuPdb

Target id: 1877

Nomenclature: CD30

Systematic Nomenclature: TNFRSF8

Family: Tumour necrosis factor (TNF) receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 595 01p36.22 TNFRSF8 TNF receptor superfamily member 8
Mouse 1 498 Tnfrsf8 tumor necrosis factor receptor superfamily
Rat 1 493 Tnfrsf8 TNF receptor superfamily member 8
Previous and Unofficial Names
CD30L receptor | tumor necrosis factor receptor superfamily, member 8 | tumor necrosis factor receptor superfamily
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Natural/Endogenous Ligands
CD30 ligand {Sp: Human}
Adaptor proteins (Human)
TRAF1, TRAF2, TRAF3, TRAF5

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Parameter Reference
AFM13 Hs Binding 8.0 pKd 1
pKd 8.0 (Kd 9.3x10-9 M) [1]
Description: Binding to CD30 determined in a competition assay on KARPAS-299 cells.
brentuximab vedotin Hs Inhibition - -
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
CD30 ligand {Sp: Human} Hs - - -
Immunopharmacology Comments
Expressed by activated T and B cells. Interacts with TRAF2 and TRAF5 to elicit downstream signalling events (NF-κB activation). CD30 may protect against autoimmunity by limiting the proliferative potential of autoreactive CD8 effector T cells. CD30 is the target of the approved anti-lymphoma monoclonal antibody drug brentuximab vedotin.
Cell Type Associations
Immuno Cell Type:  B cells
Comment:  CD30 is expressed by activated, but not by resting, T and B cells.
Immuno Cell Type:  T cells
Comment:  CD30 is expressed by activated, but not by resting, T and B cells.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0006954 inflammatory response IBA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 4 GO processes
GO:0005031 tumor necrosis factor-activated receptor activity IBA
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS
GO:0042535 positive regulation of tumor necrosis factor biosynthetic process IDA
GO:0045556 positive regulation of TRAIL biosynthetic process IDA

References

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1. Reusch U, Burkhardt C, Fucek I, Le Gall F, Le Gall M, Hoffmann K, Knackmuss SH, Kiprijanov S, Little M, Zhukovsky EA. (2014) A novel tetravalent bispecific TandAb (CD30/CD16A) efficiently recruits NK cells for the lysis of CD30+ tumor cells. MAbs, 6 (3): 728-39. [PMID:24670809]

Contributors

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How to cite this page

David MacEwan.
Tumour necrosis factor (TNF) receptor family: CD30. Last modified on 29/08/2018. Accessed on 24/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1877.