Tumour necrosis factor (TNF) receptor family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The TNF receptor superfamily (TNFRSF, provisional nomenclature) displays limited homology beyond an extracellular domain rich in cysteine residues and is activated by at least 18 different human homologues of TNF referred to as the TNF superfamily (TNFSF). Some homologues lacking transmembrane and cytoplasmic domains function as decoy receptors binding ligand without inducing cell signalling. Many of these receptors and ligands function as multimeric entities. Signalling through these receptors is complex and involves interaction with cytoplasmic adaptor proteins (such as TRADD and TRAF1). Several of these receptors contain cytoplasmic motifs known as ‘death domains’, which upon activation serve to recruit death domain- and death effector domain-containing proteins crucial for the initiation of an apoptotic response. Additional signalling pathways include the regulation of the nuclear factor κB or mitogen-activated protein kinase pathways. Pharmacological manipulation of these receptors is mainly enacted through chelating the endogenous agonists with humanised monoclonal antibodies (e.g. Infliximab or adalimumab) or recombinant fusion proteins of IgG and soluble receptors (e.g. etanercept). Some mutated forms of TNF ligands are capable of selecting for different receptor subtypes.


TNFR1 (tumor necrosis factor receptor 1 / TNFRSF1A) Show summary »

TNFR2 (tumor necrosis factor receptor 2 / TNFRSF1B) Show summary »

lymphotoxin β receptor / TNFRSF3 Show summary »

OX40 / TNFRSF4 Show summary » More detailed page

CD40 / TNFRSF5 Show summary »

Fas / TNFRSF6 Show summary » More detailed page

decoy receptor 3 / TNFRSF6B Show summary »

CD27 / TNFRSF7 Show summary »

CD30 / TNFRSF8 Show summary »

4-1BB / TNFRSF9 Show summary » More detailed page

DR4 (death receptor 4 / TNFRSF10A) Show summary »

DR5 (death receptor 5 / TNFRSF10B) Show summary »

decoy receptor 1 / TNFRSF10C Show summary »

decoy receptor 2 / TNFRSF10D Show summary »

RANK (receptor activator of NF-kappa B / TNFRSF11A) Show summary »

OPG (osteoprotegerin / TNFRSF11B) Show summary »

DR3 (death receptor 3 / TNFRSF25) Show summary »

TWEAK receptor / TNFRSF12A Show summary »

TACI / TNFRSF13B Show summary »

BAFF-R (BAFF receptor / TNFRSF13C) Show summary »

HVEM (herpes virus entry mediator / TNFRSF14) Show summary »

nerve growth factor receptor / TNFRSF16 Show summary »

BCMA (B cell maturation antigen / TNFRSF17) Show summary »

GITR (glucocorticoid-induced TNF receptor / TNFRSF18) Show summary »

TAJ (toxicity and JNK inducer / TNFRSF19) Show summary »

RELT / TNFRSF19L Show summary »

DR6 (death receptor 6 / TNFRSF21) Show summary »

TNFRSF22 Show summary »

TNFRSF23 Show summary »

ectodysplasin A2 isoform receptor / TNFRS27 Show summary »

ectodysplasin 1, anhidrotic receptor Show summary »


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Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

David MacEwan. Tumour necrosis factor (TNF) receptor family. Accessed on 24/02/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=334.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors. Br J Pharmacol. 172: 5979-6023.