toxicity and JNK inducer | Tumour necrosis factor (TNF) receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

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toxicity and JNK inducer

Target not currently curated in GtoImmuPdb

Target id: 1891

Nomenclature: toxicity and JNK inducer

Abbreviated Name: TAJ

Systematic Nomenclature: TNFRSF19

Family: Tumour necrosis factor (TNF) receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - TNFRSF19 TNF receptor superfamily member 19
Mouse - - Tnfrsf19 tumor necrosis factor receptor superfamily
Rat - - Tnfrsf19 TNF receptor superfamily member 19
Previous and Unofficial Names
TRADE | TROY | tumor necrosis factor receptor superfamily, member 19 | TAJ-alpha | tumor necrosis factor receptor superfamily member 19 | tumor necrosis factor receptor superfamily
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
Natural/Endogenous Ligands
lymphotoxin-α {Sp: Human}
Adaptor proteins (Human)
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
lymphotoxin-α {Sp: Human} N/A - - -
General Comments
TNFRSF19 protein, also known as JAC or TROY, has been implicated in the migratory potential of microglial cells in glioblastoma multiforme (GBM) [2]. Propentofylline (PubChem CID 4938), a compound with central nervous system glial modulating, neuroprotective and anti-inflammatory actions reduces rodent model GBM growth in a JAC-dependent manner [1,3].


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1. Dhruv HD, Roos A, Tomboc PJ, Tuncali S, Chavez A, Mathews I, Berens ME, Loftus JC, Tran NL. (2016) Propentofylline inhibits glioblastoma cell invasion and survival by targeting the TROY signaling pathway. J. Neurooncol., 126 (3): 397-404. [PMID:26559543]

2. Jacobs VL, Landry RP, Liu Y, Romero-Sandoval EA, De Leo JA. (2012) Propentofylline decreases tumor growth in a rodent model of glioblastoma multiforme by a direct mechanism on microglia. Neuro-oncology, 14 (2): 119-31. [PMID:22086978]

3. Jacobs VL, Liu Y, De Leo JA. (2012) Propentofylline targets TROY, a novel microglial signaling pathway. PLoS ONE, 7 (5): e37955. [PMID:22649568]


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How to cite this page

David MacEwan.
Tumour necrosis factor (TNF) receptor family: toxicity and JNK inducer. Last modified on 25/04/2017. Accessed on 20/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY,