Interleukin-10 receptor

Target id: 1900

Nomenclature: Interleukin-10 receptor

Family: IL-10 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin-10 receptor has curated GtoImmuPdb data

Quaternary Structure: Subunits
Interleukin 10 receptor, α subunit (Ligand-binding subunit)
Interleukin 10 receptor, β subunit (Other subunit)

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Agonists
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Ligand Sp. Action Affinity Units Reference
IL-10 {Sp: Human} Hs Agonist - -
Immunopharmacology Comments
The IL-10 receptor is a heteromeric complex containing two ligand binding α subunits (IL10RA) and two signal-transducing β subunits (IL10RB) [1]. Ligand binding leads to JAK/STAT signalling.

References

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1. Mosser DM, Zhang X. (2008) Interleukin-10: new perspectives on an old cytokine. Immunol. Rev.226: 205-18. [PMID:19161426]

How to cite this page

IL-10 receptor family: Interleukin-10 receptor. Last modified on 10/04/2017. Accessed on 17/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1900.