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target has curated data in GtoImmuPdb
Target id: 1906
Nomenclature: Interleukin-33 receptor
| Quaternary Structure: Subunits |
| Interleukin-1 receptor-like 1 (Ligand-binding subunit) |
| IL-1 receptor accessory protein (Other subunit) |
Natural/Endogenous Ligands  |
| IL-33 {Sp: Human} |
| Antibody Comments | ||
| The anti-IL33R immunomodulatory monoclonal CNTO 7160 (Janssen Research & Development) has entered Phase I clinical trial in patients with asthma and atopic dermatitis (see NCT02345928). |
| Immunopharmacology Comments |
| The functional IL-33 receptor is a heterodimer containing interleukin-1 receptor-like 1 (IL1RL1) as the ligand binding moeity and the IL-1 receptor accessory protein (IL1RAP). |
Immunoglobulin-like family of IL-1 receptors: Interleukin-33 receptor. Last modified on 22/03/2017. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1906.
