integrin linked kinase | ILK subfamily | IUPHAR/BPS Guide to PHARMACOLOGY

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integrin linked kinase

Target not currently curated in GtoImmuPdb

Target id: 2041

Nomenclature: integrin linked kinase

Abbreviated Name: ILK

Family: ILK subfamily

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 452 11p15.4 ILK integrin linked kinase
Mouse - 452 7 E1 Ilk integrin linked kinase
Rat - 452 1 q33 Ilk integrin-linked kinase
Previous and Unofficial Names
ILK1 | ILK2 | p59ILK | integrin-linked kinase
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain
PDB Id:  3F6Q
Resolution:  1.6Å
Species:  Human
References:  1
Enzyme Reaction
EC Number:

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
compound 22 [PMID: 21823616] Hs Inhibition 6.2 pIC50 2
pIC50 6.2 (IC50 6x10-7 M) [2]


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1. Chiswell BP, Zhang R, Murphy JW, Boggon TJ, Calderwood DA. (2008) The structural basis of integrin-linked kinase-PINCH interactions. Proc. Natl. Acad. Sci. U.S.A., 105 (52): 20677-82. [PMID:19074270]

2. Lee SL, Hsu EC, Chou CC, Chuang HC, Bai LY, Kulp SK, Chen CS. (2011) Identification and characterization of a novel integrin-linked kinase inhibitor. J. Med. Chem., 54 (18): 6364-74. [PMID:21823616]

How to cite this page

ILK subfamily: integrin linked kinase. Last modified on 29/01/2016. Accessed on 26/03/2019. IUPHAR/BPS Guide to PHARMACOLOGY,