kalirin RhoGEF kinase | Trio family | IUPHAR/BPS Guide to PHARMACOLOGY

kalirin RhoGEF kinase

Target id: 2050

Nomenclature: kalirin RhoGEF kinase

Abbreviated Name: Trad

Family: Trio family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for kalirin RhoGEF kinase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 2986 3q21.2 KALRN kalirin RhoGEF kinase
Mouse - 1654 16 B3 Kalrn kalirin, RhoGEF kinase
Rat - 2977 11 q22 Kalrn kalirin, RhoGEF kinase
Previous and Unofficial Names
cyclin B1 | DUET | HAPIP | huntingtin-associated protein interacting protein (duo) | PAM COOH-terminal interactor protein 10 | P-CIP10 | TRAD | kalirin | kalirin, RhoGEF kinase
Database Links
BRENDA
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Solution structure of rat Kalirin N-terminal SH3 domain
PDB Id:  1U3O
Resolution:  0.0Å
Species:  Human
References:  1
Enzyme Reaction
EC Number: 2.7.11.1
Clinically-Relevant Mutations and Pathophysiology
Disease:  Coronary heart disease, susceptibility to, 5
Synonyms: Coronary heart disease [Disease Ontology: DOID:3393]
Disease Ontology: DOID:3393
OMIM: 608901

References

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1. Schiller MR, Chakrabarti K, King GF, Schiller NI, Eipper BA, Maciejewski MW. (2006) Regulation of RhoGEF activity by intramolecular and intermolecular SH3 domain interactions. J. Biol. Chem., 281 (27): 18774-86. [PMID:16644733]

How to cite this page

Trio family: kalirin RhoGEF kinase. Last modified on 23/05/2017. Accessed on 15/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2050.