kalirin RhoGEF kinase | Trio family | IUPHAR/BPS Guide to PHARMACOLOGY

kalirin RhoGEF kinase

Target id: 2050

Nomenclature: kalirin RhoGEF kinase

Abbreviated Name: Trad

Family: Trio family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for kalirin RhoGEF kinase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 2986 3q21.2 KALRN kalirin RhoGEF kinase
Mouse - 1654 16 B3 Kalrn kalirin, RhoGEF kinase
Rat - 2977 11 q22 Kalrn kalirin, RhoGEF kinase
Previous and Unofficial Names
cyclin B1 | DUET | HAPIP | huntingtin-associated protein interacting protein (duo) | PAM COOH-terminal interactor protein 10 | P-CIP10 | TRAD | kalirin | kalirin, RhoGEF kinase
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Solution structure of rat Kalirin N-terminal SH3 domain
PDB Id:  1U3O
Resolution:  0.0Å
Species:  Human
References:  1
Enzyme Reaction
EC Number:
Clinically-Relevant Mutations and Pathophysiology
Disease:  Coronary heart disease, susceptibility to, 5
Synonyms: Coronary heart disease [Disease Ontology: DOID:3393]
Disease Ontology: DOID:3393
OMIM: 608901


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1. Schiller MR, Chakrabarti K, King GF, Schiller NI, Eipper BA, Maciejewski MW. (2006) Regulation of RhoGEF activity by intramolecular and intermolecular SH3 domain interactions. J. Biol. Chem., 281 (27): 18774-86. [PMID:16644733]

How to cite this page

Trio family: kalirin RhoGEF kinase. Last modified on 23/05/2017. Accessed on 15/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2050.