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kalirin RhoGEF kinase

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Target not currently curated in GtoImmuPdb

Target id: 2050

Nomenclature: kalirin RhoGEF kinase

Abbreviated Name: Trad

Family: Trio family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 2986 3q21.1-q21.2 KALRN kalirin RhoGEF kinase
Mouse - 2964 16 B3 Kalrn kalirin, RhoGEF kinase
Rat - 2959 11q22 Kalrn kalirin, RhoGEF kinase
Previous and Unofficial Names Click here for help
cyclin B1 | DUET | HAPIP | huntingtin-associated protein interacting protein (duo) | PAM COOH-terminal interactor protein 10 | P-CIP10 | TRAD | kalirin, RhoGEF kinase | kalirin
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Solution structure of rat Kalirin N-terminal SH3 domain
PDB Id:  1U3O
Resolution:  0.0Å
Species:  Human
References:  1
Enzyme Reaction Click here for help
EC Number:
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Coronary heart disease, susceptibility to, 5
Synonyms: Coronary heart disease [Disease Ontology: DOID:3393]
Disease Ontology: DOID:3393
OMIM: 608901


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1. Schiller MR, Chakrabarti K, King GF, Schiller NI, Eipper BA, Maciejewski MW. (2006) Regulation of RhoGEF activity by intramolecular and intermolecular SH3 domain interactions. J Biol Chem, 281 (27): 18774-86. [PMID:16644733]

How to cite this page

Trio family: kalirin RhoGEF kinase. Last modified on 23/05/2017. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY,