NIMA related kinase 9 | NIMA (never in mitosis gene a)- related kinase (NEK) family | IUPHAR/BPS Guide to PHARMACOLOGY

NIMA related kinase 9

Target id: 2124

Nomenclature: NIMA related kinase 9

Abbreviated Name: NEK9

Family: NIMA (never in mitosis gene a)- related kinase (NEK) family

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for NIMA related kinase 9 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 979 14q24.2 NEK9 NIMA related kinase 9
Mouse - 984 12 D2 Nek9 NIMA (never in mitosis gene a)-related expressed kinase 9
Rat - 958 6 q31 Nek9 NIMA-related kinase 9
Previous and Unofficial Names
NERCC | NIMA-related kinase 9
Database Links
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.1
EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: ...1

Key to terms and symbols Click column headers to sort
Target used in screen: nd/NEK9
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
K-252a Hs Inhibitor Inhibition 14.7
SB 218078 Hs Inhibitor Inhibition 23.4
staurosporine Hs Inhibitor Inhibition 27.2
PKR inhibitor Hs Inhibitor Inhibition 32.0
Cdk1/2 inhibitor III Hs Inhibitor Inhibition 39.1
dovitinib Hs Inhibitor Inhibition 58.9
midostaurin Hs Inhibitor Inhibition 64.4
JAK3 inhibitor VI Hs Inhibitor Inhibition 66.3
Syk inhibitor Hs Inhibitor Inhibition 67.3
aminopurvalanol A Hs Inhibitor Inhibition 69.4
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1039-45. [PMID:22037377]

How to cite this page

NIMA (never in mitosis gene a)- related kinase (NEK) family: NIMA related kinase 9. Last modified on 29/01/2016. Accessed on 20/10/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2124.