phosphatidylinositol-5-phosphate 4-kinase type 2 beta

Target id: 2162

Nomenclature: phosphatidylinositol-5-phosphate 4-kinase type 2 beta

Abbreviated Name: PIP4K2B

Family: Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family), Phosphatidylinositol phosphate kinases

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for phosphatidylinositol-5-phosphate 4-kinase type 2 beta in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 603 17q21.2 PIP4K2B phosphatidylinositol-5-phosphate 4-kinase type 2 beta
Mouse - 603 11 D Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta
Rat - 416 10 q31 Pip4k2b phosphatidylinositol-5-phosphate 4-kinase type 2 beta
Previous and Unofficial Names
PI5P4Kbeta | diphosphoinositide kinase 2-beta | 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta | 1-phosphatidylinositol-5-phosphate 4-kinase B | PIP4KII-beta | PIP5K2B | PIP5KIIB | phosphatidylinositol-5-phosphate 4-kinase, type II, beta | phosphatidylinositol-5-phosphate 4-kinase
Database Links
BRENDA
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  PHOSPHATIDYLINOSITOL PHOSPHATE KINASE TYPE II BETA
PDB Id:  1BO1
Resolution:  3.0Å
Species:  Human
References:  2
Enzyme Reaction
EC Number: 2.7.1.149
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1,3

Key to terms and symbols Click column headers to sort
Target used in screen: PIP5K2B
Ligand Sp. Type Action Affinity Units
lestaurtinib Hs Inhibitor Inhibition 7.7 pKd
sunitinib Hs Inhibitor Inhibition 7.4 pKd
staurosporine Hs Inhibitor Inhibition 7.1 pKd
KW-2449 Hs Inhibitor Inhibition 7.0 pKd
tozasertib Hs Inhibitor Inhibition 6.8 pKd
fedratinib Hs Inhibitor Inhibition 6.8 pKd
dovitinib Hs Inhibitor Inhibition 6.6 pKd
SU-14813 Hs Inhibitor Inhibition 6.6 pKd
midostaurin Hs Inhibitor Inhibition 6.6 pKd
ruboxistaurin Hs Inhibitor Inhibition 6.1 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol.29 (11): 1046-51. [PMID:22037378]

2. Rao VD, Misra S, Boronenkov IV, Anderson RA, Hurley JH. (1998) Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation. Cell94 (6): 829-39. [PMID:9753329]

3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol.17 (11): 1241-9. [PMID:21095574]

How to cite this page

Phosphatidylinositol phosphate kinases: phosphatidylinositol-5-phosphate 4-kinase type 2 beta. Last modified on 19/08/2015. Accessed on 24/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2162.