Interleukin-7 receptor

Target id: 2300

Nomenclature: Interleukin-7 receptor

Family: IL-2 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin-7 receptor has curated GtoImmuPdb data

Quaternary Structure: Subunits
Interleukin-7 receptor subunit α (Ligand-binding subunit)
Interleukin-2 receptor subunit γ (Other subunit)

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Agonists
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Ligand Sp. Action Affinity Units Reference
IL-7 {Sp: Human} Hs Agonist - -
Immunopharmacology Comments
The functional IL-7 receptor is a heterodimer consisting of the ligand binding interleukin-7 receptor subunit α (IL7R) and a common-γ chain signal transducing subunit (interleukin-2 receptor subunit γ, IL2RG). IL2RG is shared with various cytokine receptors, including those for interleukin-2, -4, -9, and -15.

Targeting the IL-7/IL-7R pathway is being investigated as a novel intervention in autoimmune diseases, given IL-7's role in autoimmune inflammation [1-6].

References

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1. Dooms H. (2013) Interleukin-7: Fuel for the autoimmune attack. J. Autoimmun.45: 40-8. [PMID:23831438]

2. Lee LF, Logronio K, Tu GH, Zhai W, Ni I, Mei L, Dilley J, Yu J, Rajpal A, Brown C et al.. (2012) Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function. Proc. Natl. Acad. Sci. U.S.A.109 (31): 12674-9. [PMID:22733769]

3. Penaranda C, Kuswanto W, Hofmann J, Kenefeck R, Narendran P, Walker LS, Bluestone JA, Abbas AK, Dooms H. (2012) IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells. Proc. Natl. Acad. Sci. U.S.A.109 (31): 12668-73. [PMID:22733744]

4. Shinohara T, Nemoto Y, Kanai T, Kameyama K, Okamoto R, Tsuchiya K, Nakamura T, Totsuka T, Ikuta K, Watanabe M. (2011) Upregulated IL-7 receptor α expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis. J. Immunol.186 (4): 2623-32. [PMID:21217010]

5. Totsuka T, Kanai T, Nemoto Y, Makita S, Okamoto R, Tsuchiya K, Watanabe M. (2007) IL-7 Is essential for the development and the persistence of chronic colitis. J. Immunol.178 (8): 4737-48. [PMID:17404253]

6. Willis CR, Seamons A, Maxwell J, Treuting PM, Nelson L, Chen G, Phelps S, Smith CL, Brabb T, Iritani BM et al.. (2012) Interleukin-7 receptor blockade suppresses adaptive and innate inflammatory responses in experimental colitis. J Inflamm (Lond)9 (1): 39. [PMID:23057802]

How to cite this page

IL-2 receptor family: Interleukin-7 receptor. Last modified on 19/07/2017. Accessed on 13/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2300.