proprotein convertase subtilisin/kexin type 4 | S8: Subtilisin | IUPHAR/BPS Guide to PHARMACOLOGY

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proprotein convertase subtilisin/kexin type 4

Target not currently curated in GtoImmuPdb

Target id: 2384

Nomenclature: proprotein convertase subtilisin/kexin type 4

Family: S8: Subtilisin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 755 19p13.3 PCSK4 proprotein convertase subtilisin/kexin type 4
Mouse - 655 10 C1 Pcsk4 proprotein convertase subtilisin/kexin type 4
Rat - 654 7q11 Pcsk4 proprotein convertase subtilisin/kexin type 4
Previous and Unofficial Names
NEC 3 | neuroendocrine convertase 3 | PC4 | prohormone convertase 3 | SPC5
Database Links
Specialist databases
MEROPS S08.074 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
furin inhibitor peptide Hs Inhibition 6.4 pKi 1
pKi 6.4 (Ki 4.41x10-7 M) [1]


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1. Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R et al.. (2007) Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J. Biol. Chem., 282 (29): 20847-53. [PMID:17537721]

How to cite this page

S8: Subtilisin: proprotein convertase subtilisin/kexin type 4. Last modified on 28/07/2015. Accessed on 20/03/2019. IUPHAR/BPS Guide to PHARMACOLOGY,