proteasome subunit beta 2 | T1: Proteasome | IUPHAR/BPS Guide to PHARMACOLOGY

proteasome subunit beta 2

Target id: 2405

Nomenclature: proteasome subunit beta 2

Family: T1: Proteasome

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for proteasome subunit beta 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 201 1p34.2 PSMB2 proteasome subunit beta 2
Mouse - 201 4 D2.2 Psmb2 proteasome (prosome, macropain) subunit, beta type 2
Rat - 201 5q36 Psmb2 proteasome subunit beta 2
Previous and Unofficial Names
macropain subunit C7-I | multicatalytic endopeptidase complex subunit C7-I | proteasome beta 2 subunit | proteasome (prosome, macropain) subunit, beta type 2 | proteasome (prosome, macropain) subunit, beta type, 2 | proteasome (prosome
Database Links
Specialist databases
MEROPS T01.984 (Hs)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 5b [PMID: 16686537] N/A Inhibition 6.5 pKi 1
pKi 6.5 (Ki 3x10-7 M) [1]


Show »

1. Rydzewski RM, Burrill L, Mendonca R, Palmer JT, Rice M, Tahilramani R, Bass KE, Leung L, Gjerstad E, Janc JW et al.. (2006) Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and cellular properties of potent, selective proteasome inhibitors. J. Med. Chem., 49 (10): 2953-68. [PMID:16686537]

How to cite this page

T1: Proteasome: proteasome subunit beta 2. Last modified on 15/10/2015. Accessed on 25/09/2018. IUPHAR/BPS Guide to PHARMACOLOGY,