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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 201 | 1p34.3 | PSMB2 | proteasome 20S subunit beta 2 | |
Mouse | - | 201 | 4 60.9 cM | Psmb2 | proteasome (prosome, macropain) subunit, beta type 2 | |
Rat | - | 201 | 5q36 | Psmb2 | proteasome 20S subunit beta 2 |
Database Links ![]() |
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Specialist databases | |
MEROPS | T01.984 (Hs) |
Other databases | |
Alphafold | P49721 (Hs), Q9R1P3 (Mm), P40307 (Rn) |
BRENDA | 3.4.25.1 |
CATH/Gene3D | 3.60.20.10 |
ChEMBL Target | CHEMBL3492 (Hs), CHEMBL3112378 (Mm) |
DrugBank Target | P49721 (Hs) |
Ensembl Gene | ENSG00000126067 (Hs), ENSMUSG00000028837 (Mm), ENSRNOG00000011463 (Rn) |
Entrez Gene | 5690 (Hs), 26445 (Mm), 29675 (Rn) |
Human Protein Atlas | ENSG00000126067 (Hs) |
KEGG Enzyme | 3.4.25.1 |
KEGG Gene | hsa:5690 (Hs), mmu:26445 (Mm), rno:29675 (Rn) |
OMIM | 602175 (Hs) |
Pharos | P49721 (Hs) |
RefSeq Nucleotide | NM_002794 (Hs), NM_011970 (Mm), NM_017284 (Rn) |
RefSeq Protein | NP_002785 (Hs), NP_036100 (Mm), NP_058980 (Rn) |
UniProtKB | P49721 (Hs), Q9R1P3 (Mm), P40307 (Rn) |
Wikipedia | PSMB2 (Hs) |
Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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View species-specific inhibitor tables |
Immuno Process Associations | ||
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1. Johnson HWB, Lowe E, Anderl JL, Fan A, Muchamuel T, Bowers S, Moebius DC, Kirk C, McMinn DL. (2018) Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2 S,3 R)- N-(( S)-3-(Cyclopent-1-en-1-yl)-1-(( R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-(( S)-2-(2-morpholinoacetamido)propanamido)propenamide). J Med Chem, 61 (24): 11127-11143. [PMID:30380863]
2. Rydzewski RM, Burrill L, Mendonca R, Palmer JT, Rice M, Tahilramani R, Bass KE, Leung L, Gjerstad E, Janc JW et al.. (2006) Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and cellular properties of potent, selective proteasome inhibitors. J Med Chem, 49 (10): 2953-68. [PMID:16686537]
T1: Proteasome: proteasome 20S subunit beta 2. Last modified on 12/09/2019. Accessed on 12/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2405.