glutaminyl-peptide cyclotransferase

Target id: 2411

Nomenclature: glutaminyl-peptide cyclotransferase

Family: M28: Aminopeptidase Y

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for glutaminyl-peptide cyclotransferase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 361 2p22 QPCT glutaminyl-peptide cyclotransferase
Mouse - 362 17 E3 Qpct glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
Rat - 313 6q11 Qpct glutaminyl-peptide cyclotransferase
Previous and Unofficial Names
GCT | glutaminyl cyclase | glutaminyl-tRNA cyclotransferase | QC
Database Links
Specialist databases
MEROPS M28.974 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.3.2.5

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
PBD150 Hs Inhibition 7.2 pKi 1
pKi 7.2 (Ki 6x10-8 M) [1]

References

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1. Buchholz M, Heiser U, Schilling S, Niestroj AJ, Zunkel K, Demuth HU. (2006) The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship. J. Med. Chem.49 (2): 664-77. [PMID:16420052]

How to cite this page

M28: Aminopeptidase Y: glutaminyl-peptide cyclotransferase. Last modified on 23/06/2015. Accessed on 24/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2411.