steroid 5 alpha-reductase 2

Target id: 2633

Nomenclature: steroid 5 alpha-reductase 2

Family: 1.-.-.- Oxidoreductases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for steroid 5 alpha-reductase 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 254 2p23.1 SRD5A2 steroid 5 alpha-reductase 2
Mouse - 254 17 E2 Srd5a2 steroid 5 alpha-reductase 2
Rat - 254 6q13 Srd5a2 steroid 5 alpha-reductase 2
Previous and Unofficial Names
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
Database Links
BRENDA
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.3.99.5

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
finasteride Hs Inhibition 7.8 pIC50 1
pIC50 7.8 (IC50 1.46x10-8 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency
Synonyms: Pseudovaginal perineoscrotal hypospadias; PPSH [OMIM: 264600]
OMIM: 264600
Orphanet: ORPHA753
Disease:  Familial prostate cancer
Synonyms: Prostate cancer [OMIM: 176807] [Disease Ontology: DOID:10283]
Disease Ontology: DOID:10283
OMIM: 176807
Orphanet: ORPHA1331

References

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1. Rasmusson GH, Reynolds GF, Steinberg NG, Walton E, Patel GF, Liang T, Cascieri MA, Cheung AH, Brooks JR, Berman C. (1986) Azasteroids: structure-activity relationships for inhibition of 5 alpha-reductase and of androgen receptor binding. J. Med. Chem.29 (11): 2298-315. [PMID:3783591]

How to cite this page

1.-.-.- Oxidoreductases: steroid 5 alpha-reductase 2. Last modified on 30/03/2016. Accessed on 13/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2633.