egl-9 family hypoxia inducible factor 3

Target id: 2834

Nomenclature: egl-9 family hypoxia inducible factor 3

Abbreviated Name: PHD3

Family: 1.14.11.29 2-oxoglutarate oxygenases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for egl-9 family hypoxia inducible factor 3 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 239 14q12 EGLN3 egl-9 family hypoxia inducible factor 3
Mouse - 239 12 C1 Egln3 egl-9 family hypoxia-inducible factor 3
Rat - 355 6q23 Egln3 egl-9 family hypoxia-inducible factor 3
Previous and Unofficial Names
EGL nine (C.elegans) homolog 3 | HIF prolyl hydroxylase 3 | HIFPH3 | egl-9 family hypoxia-inducible factor 3
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.14.11.29

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 6ee [PMID: 22364528] Hs Inhibition 8.5 pIC50 2
pIC50 8.5 (IC50 3.5x10-9 M) [2]
molidustat Hs Inhibition 6.3 pIC50 1
pIC50 6.3 (IC50 4.9x10-7 M) [1]

References

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1. Thede K et al.. (2014) Substituted dihydropyrazolones for treating cardiovascular and hematological diseases. Patent number: US8653111 B2. Assignee: Bayer Intellectual Property Gmbh.. Priority date: 26/10/2006. Publication date: 18/02/2014.

2. Vachal P, Miao S, Pierce JM, Guiadeen D, Colandrea VJ, Wyvratt MJ, Salowe SP, Sonatore LM, Milligan JA, Hajdu R et al.. (2012) 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia. J. Med. Chem.55 (7): 2945-59. [PMID:22364528]

How to cite this page

1.14.11.29 2-oxoglutarate oxygenases: egl-9 family hypoxia inducible factor 3. Last modified on 17/07/2017. Accessed on 24/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2834.