Plasmodium falciparum dihydroorotate dehydrogenase

Target id: 2949

Nomenclature: Plasmodium falciparum dihydroorotate dehydrogenase

Abbreviated Name: PfDHODH

Family: Anti-infective targets

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Plasmodium falciparum dihydroorotate dehydrogenase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum - 569 DHODH dihydroorotate dehydrogenase
Previous and Unofficial Names
Pfal DHODH
Database Links
SynPHARM
UniProtKB

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Inhibitors
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Ligand Sp. Action Affinity Units Reference
DSM265 Pf Inhibition 7.5 pIC50 1
pIC50 7.5 (IC50 3x10-8 M) [1]
General Comments
The pyrimidine biosynthetic pathway has facilitated the successful identification of anti-malarial drug targets. These include the fourth enzyme in the pathway as P. falciparum dihydroorotate dehydrogenase (PfDHODH) [2]. In this publication they established that the cross reactivity with human DHODH was orders of magnitude lower.

References

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1. Phillips MA, Lotharius J, Marsh K, White J, Dayan A, White KL, Njoroge JW, El Mazouni F, Lao Y, Kokkonda S et al.. (2015) A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Sci Transl Med7 (296): 296ra111. [PMID:26180101]

2. Phillips MA, Rathod PK. (2010) Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy. Infect Disord Drug Targets10 (3): 226-39. [PMID:20334617]

How to cite this page

Anti-infective targets: Plasmodium falciparum dihydroorotate dehydrogenase. Last modified on 28/11/2017. Accessed on 14/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2949.