Plasmodium falciparum dihydroorotate dehydrogenase

Target id: 2949

Nomenclature: Plasmodium falciparum dihydroorotate dehydrogenase

Abbreviated Name: PfDHODH

Family: Antimalarial targets

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Plasmodium falciparum dihydroorotate dehydrogenase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 569 DHODH dihydroorotate dehydrogenase
Previous and Unofficial Names
Pfal DHODH
Database Links
UniProtKB
Whole Organism Assay Data Linked to This Target
Key to terms and symbols Click column headers to sort
Ligand Sp. Assay description Type Action Affinity Units Reference
DSM265 PfNF54 Parasite growth inhibition assay - - 7.5 pIC50 1
pIC50 7.5 (IC50 3x10-8 M) [3H]-hypoxanthine incorporation [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
General Comments
The pyrimidine biosynthetic pathway has facilitated the successful identification of antimalarial drug targets. These include the fourth enzyme in the pathway as P. falciparum dihydroorotate dehydrogenase (PfDHODH) [2]. In this publication they established that the cross reactivity with human DHODH was orders of magnitude lower.

References

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1. Phillips MA, Lotharius J, Marsh K, White J, Dayan A, White KL, Njoroge JW, El Mazouni F, Lao Y, Kokkonda S et al.. (2015) A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Sci Transl Med, 7 (296): 296ra111. [PMID:26180101]

2. Phillips MA, Rathod PK. (2010) Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy. Infect Disord Drug Targets, 10 (3): 226-39. [PMID:20334617]

How to cite this page

Antimalarial targets: Plasmodium falciparum dihydroorotate dehydrogenase. Last modified on 08/05/2018. Accessed on 15/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2949.