B2 receptor

Target id: 42

Nomenclature: B2 receptor

Family: Bradykinin receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     B2 receptor has curated GtoImmuPdb data

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 391 14q32.1-q32.2 BDKRB2 bradykinin receptor B2 60
Mouse 7 392 12 E Bdkrb2 bradykinin receptor, beta 2
Rat 7 396 6q32 Bdkrb2 bradykinin receptor B2 54
Previous and Unofficial Names
B2BKR | B2BRA | BK-2 receptor | BK2R
Database Links
Specialist databases
GPCRDB bkrb2_human (Hs), bkrb2_mouse (Mm), bkrb2_rat (Rn)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands
bradykinin {Sp: Human, Mouse, Rat}
[des-Arg9]bradykinin {Sp: Human, Mouse, Rat}
[des-Arg10]kallidin {Sp: Human}
[Hyp3]bradykinin {Sp: Human}
kallidin {Sp: Human}
Lys-[Hyp3]-bradykinin {Sp: Human, Mouse, Rat}
T-kinin {Sp: Human, Rat}
Comments: Bradykinin and kallidin are the most potent endogenous ligands
Potency order of endogenous ligands (Human)
kallidin (KNG1, P01042) > bradykinin (KNG1, P01042) >> [des-Arg9]bradykinin (KNG1, P01042), [des-Arg10]kallidin (KNG1, P01042)

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[3H]BK (human, mouse, rat) Mm Full agonist 9.4 pKd 81
pKd 9.4 (Kd 3.99x10-10 M) [81]
JMV1116 Rn Full agonist 10.0 – 10.2 pKi 4
pKi 10.0 – 10.2 [4]
JMV1116 Hs Full agonist 9.1 – 9.2 pKi 4
pKi 9.1 – 9.2 [4]
labradimil Rn Full agonist 7.7 – 8.0 pKi 4,22
pKi 7.7 – 8.0 [4,22]
FR190997 Hs Full agonist 7.3 pKi 5
pKi 7.3 [5]
bradykinin {Sp: Human, Mouse, Rat} Mm Full agonist 9.3 pIC50 40
pIC50 9.3 [40]
kallidin {Sp: Human} Hs Full agonist 9.3 pIC50 40
pIC50 9.3 [40]
kallidin {Sp: Human} Mm Full agonist 9.3 pIC50 40
pIC50 9.3 [40]
FR191413 Hs Full agonist 9.2 pIC50 69
pIC50 9.2 [69]
Met-Lys-bradykinin Hs Full agonist 8.7 pIC50 40
pIC50 8.7 [40]
Met-Lys-bradykinin Mm Full agonist 8.4 pIC50 40
pIC50 8.4 [40]
bradykinin {Sp: Human, Mouse, Rat} Hs Full agonist 7.0 – 9.3 pIC50 6,40
pIC50 7.0 – 9.3 [6,40]
[Tyr8]bradykinin Mm Full agonist 8.1 pIC50 40
pIC50 8.1 [40]
[Tyr8]bradykinin Hs Full agonist 8.0 pIC50 40
pIC50 8.0 [40]
[des-Arg9]bradykinin {Sp: Human, Mouse, Rat} Mm Full agonist 5.2 pIC50 40
pIC50 5.2 [40]
[des-Arg9]bradykinin {Sp: Human, Mouse, Rat} Hs Full agonist 5.1 pIC50 40
pIC50 5.1 [40]
[des-Arg10]kallidin {Sp: Human} Mm Partial agonist 4.6 pIC50 40
pIC50 4.6 [40]
[125I][Tyr8]bradykinin Hs Full agonist - -
View species-specific agonist tables
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
icatibant Hs Antagonist 8.4 pA2 34
pA2 8.4 [34]
FR173657 Hs Antagonist 8.2 pA2 64
pA2 8.2 [64]
[3H]NPC17731 Hs Antagonist 9.1 – 9.4 pKd 86-87
pKd 9.1 – 9.4 (Kd 7.7x10-10 – 3.9x10-10 M) [86-87]
icatibant Hs Antagonist 10.2 pKi 4
pKi 10.2 (Ki 6.4x10-11 M) [4]
icatibant Rn Antagonist 10.0 – 10.3 pKi 11
pKi 10.0 – 10.3 [11]
icatibant Mm Antagonist 9.6 pKi 40
pKi 9.6 [40]
bradyzide Rn Antagonist 9.2 – 9.5 pKi 11
pKi 9.2 – 9.5 [11]
B-9430 Hs Antagonist 8.6 – 9.6 pKi 51,74
pKi 8.6 – 9.6 [51,74]
B-9430 Mm Antagonist 8.5 – 9.5 pKi 51
pKi 8.5 – 9.5 [51]
JMV1431 Hs Antagonist 8.4 pKi 3
pKi 8.4 [3]
anatibant Hs Antagonist 8.2 pKi 61
pKi 8.2 (Ki 6.31x10-9 M) [61]
NPC 17731 Hs Antagonist 8.1 pKi 47
pKi 8.1 [47]
anatibant Rn Antagonist 7.8 pKi 61
pKi 7.8 [61]
WIN 64338 Hs Antagonist 6.2 – 7.2 pKi 67,70
pKi 6.2 – 7.2 [67,70]
NPC 18565 Hs Antagonist 6.6 pKi 47
pKi 6.6 [47]
bradyzide Hs Antagonist 6.3 – 6.5 pKi 11
pKi 6.3 – 6.5 [11]
NPC-349 Mm Antagonist 8.9 pIC50 40
pIC50 8.9 [40]
icatibant Hs Antagonist 8.0 – 9.4 pIC50 6,40
pIC50 8.0 – 9.4 [6,40]
NPC-567 Mm Antagonist 8.7 pIC50 40
pIC50 8.7 [40]
FR173657 Hs Antagonist 8.1 pIC50 6
pIC50 8.1 (IC50 7.95x10-9 M) [6]
FR167344 Hs Antagonist 7.2 pIC50 6
pIC50 7.2 [6]
NPC-349 Hs Antagonist 7.0 pIC50 40
pIC50 7.0 [40]
[Thi5,8,D-Phe7]bradykinin Mm Antagonist 7.0 pIC50 40
pIC50 7.0 [40]
NPC-567 Hs Antagonist 6.9 pIC50 40
pIC50 6.9 [40]
[Thi5,8,D-Phe7]bradykinin Hs Antagonist 6.3 pIC50 40
pIC50 6.3 [40]
View species-specific antagonist tables
Immunopharmacology Comments
Bradykinin is a vasoactive, pain inducing and pro-inflammatory (phlogistic) kinin released during acute inflammation, and its receptors, B1 and B2, are expressed on eosinophils, and neutrophils. The B2 receptor antagonist icatibant was evaluated in a Phase 2 trial for osteoarthritis [20], but development has not progressed further.
Immuno Cell Type Associations
Immuno Cell Type:  Granulocytes
Cell Ontology Term:   eosinophil (CL:0000771)
neutrophil (CL:0000775)
Comment: 
References: 
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  inflammatory response (GO:0006954) IC
References: 
Primary Transduction Mechanisms
Transducer Effector/Response
Gs family
Gi/Go family
Gq/G11 family
Adenylate cyclase inhibition
Phospholipase C stimulation
Phospholipase A2 stimulation
References:  28,35,37,44,46,49-50,80
Tissue Distribution
Endothelium and tunica media of aorta and endocardium.
Species:  Human
Technique:  Immmunoblot, autoradiography.
References:  31
Medulla.
Species:  Human
Technique:  Autoradiography.
References:  21
Lung fibroblasts.
Species:  Human
Technique:  Immunohistochemistry.
References:  63
Gastric mucosa.
Species:  Human
Technique:  Immunohistochemistry.
References:  7
Clinical cancer specimens.
Species:  Human
Technique:  Immunohistochemistry.
References:  82
Murine tumor tissues.
Species:  Mouse
Technique:  Immunohistochemistry.
References:  82
Endothelium and tunica media of aorta and endocardium.
Species:  Mouse
Technique:  Immunoblot, autoradiography.
References:  31
Lateral septal nucleus, median preoptic nucleus, dentate gyrus, amygdala, spinal trigeminal nucleus, mediovestibular nucleus, inferior cerebellar peduncles, and most of cortical regions.
Species:  Rat
Technique:  Autoradiography.
References:  57
Endothelium and tunica media of the aorta and endocardium.
Species:  Rat
Technique:  Immunoblot, autoradiography.
References:  31
Endothelial linings of the aorta, other elastic arteries, muscular arteries, capillaries, venules, and large veins. Small arterioles of the mesenterium, heart, urinary bladder, brain, salivary gland.
Species:  Rat
Technique:  Immunostaining.
References:  31
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
Measurement of cyclooxygenase-2 in rat aortic vascular smooth muscle cells endogenously expressing the B2 receptor.
Species:  Rat
Tissue:  Aortic vascular smooth muscle cells.
Response measured:  Increase in cyclooxygenase-2 levels.
References:  65
Measurement of anion secretion in cultured rat epididymal monolayers endogenously expressing the B2 receptor.
Species:  Rat
Tissue:  Cultured rat epididymal monolayers.
Response measured:  Increase in anion secretion.
References:  17
Measurement of IP3 levels in rat/mouse NG108-15 neuroblastoma-glioma hybrid cells endogenously expressing the B2 receptor.
Species:  Rat
Tissue:  NG108-15 neuroblastoma-glioma hybrid cells.
Response measured:  Increase in IP3
References:  41
Measurement of cAMP in rat/mouse NG108-15 neuroblastoma-glioma hybrid cells endogenously expressing the B2 receptor.
Species:  Rat
Tissue:  NG108-15 neuroblastoma-glioma hybrid cells.
Response measured:  Increase in cAMP.
References:  41
Measurement of IP in mouse Swiss 3T3 fibroblasts endogenously expressing the B2 receptor.
Species:  Mouse
Tissue:  Swiss 3T3 fibroblasts.
Response measured:  IP formation.
References:  10
Measurement of PGE2 in mouse Swiss 3T3 fibroblasts endogenously expressing the B2 receptor.
Species:  Mouse
Tissue:  Swiss 3T3 fibroblasts.
Response measured:  Increase in PGE2.
References:  10
Measurement of levels of [3H]inositol phosphates in rat/mouse NG108-15 neuroblastoma-glioma hybrid cells.
Species:  Rat
Tissue:  NG108-15 neuroblastoma-glioma hybrid cells.
Response measured:  Increase in [3H]inositol triphosphate.
References:  85
Measurement of inositol triphosphate and intracellular free Ca2+ in human A431 epidermoid carcinoma cells endogenously expressing the B2 receptor.
Species:  Human
Tissue:  A431 epidermoid carcinoma cells.
Response measured:  Increase in inositol triphosphate and intracelluar Ca2+.
References:  75
Measurement of inositol phosphates, cytosolic free Ca2+, membrane potential and ionic currents in rat PC12 cells endogenously expressing the B2 receptor.
Species:  Rat
Tissue:  PC12 cells.
Response measured:  Accumulation of IP3, Ca2+, and hyperpolarization due to the opening of Ca2+-activated K+ channels.
References:  30
Measurement of intracellular free Ca2+ in human foreskin fibroblasts endogenously expressing the B2 receptor.
Species:  Human
Tissue:  Foreskin fibroblasts.
Response measured:  Elevation of intracellular free Ca2+ concentration.
References:  13
Measurement of translocation of PKC isoforms α, δ, ε and ζ in human foreskin fibroblasts endogenously expressing the B2 receptor and CHO cells transfected with the B2 receptor.
Species:  Human
Tissue:  CHO cells and foreskin fibroblasts.
Response measured:  Translocation of the PKC isoforms α, ε, and ζ.
References:  76
Measurement of translocation of PKC isoforms α, ε and ζ in human endothelial cells endogenously expressing the B2 receptor.
Species:  Human
Tissue:  Endothelial cells.
Response measured:  Translocation of PKC isoforms α, δ, ε and ζ.
References:  66
Measurement of IP3 and prostaglandin E2 in murine osteoblastic MC3T3-E1 cells endogenously expressing the B2 receptor.
Species:  Mouse
Tissue:  Osteoblastic MC3T3-E1 cells.
Response measured:  Accumulation of IP3 and PGE2.
References:  83
Measurement of cAMP accumulation in human airway smooth muscle cells endogenously expressing the B2 receptor.
Species:  Human
Tissue:  Airway smooth muscle cells.
Response measured:  Stimulation of cAMP accumulation via MAP kinase-dependent regulation of PLA2 and prostaglandin E2 release.
References:  62
Measurement of NO production in endothelial cells endogenously expressing the B2 receptor.
Species:  Human
Tissue:  Endothelial cells.
Response measured:  Stimulation of NO production.
References:  12
Measurement of phosphorylation of MAPK in human umbilical vein endothelial cells endogenously expressing the B2 receptor.
Species:  Human
Tissue:  Umbilical vein endothelial cells.
Response measured:  Stimulation of MAPK phosphorylation.
References:  32
Measurement of phospholipase Cγ phosphorylation in human endothelial cells endogenously expressing the B2 receptor.
Species:  Human
Tissue:  Endothelial cells.
Response measured:  Simulation of phospholipase Cγ phosphorylation.
References:  33
Measurement of epidermal growth factor receptor phosphorylation in rat PC12 cells endogenously expressing the B2 receptor.
Species:  Rat
Tissue:  PC12 cells.
Response measured:  Phosphorylation of epidermal growth factor receptor.
References:  88
Measurement of phosphorylation of focal adhesion-associated proteins p125FAK and paxillin in mouse Swiss 3T3 cells endogenously expressing the B2 receptor.
Species:  Mouse
Tissue:  Swiss 3T3 cells.
Response measured:  Phosphorylation of focal adhesion-associated proteins p125FAK and paxillin.
References:  48
Measurement of interleukin expression in human lung WI-38 fibroblasts endogenously expressing the B2 receptor.
Species:  Human
Tissue:  Lung WI-38 fibroblasts.
Response measured:  Induction of IL-1beta expression.
References:  39,58
Physiological Functions
Role in mechanism of plasma extravasation which occurs during the reverse passive Arthus reaction.
Species:  Mouse
Tissue:  In vivo.
References:  68
MOdulation of antigen-induced pulmonary inflammation.
Species:  Mouse
Tissue:  In vivo.
References:  27
Modulation of blood pressure.
Species:  Rat
Tissue:  In vivo.
References:  24
Attenuation of cardiac remodeling.
Species:  Rat
Tissue:  In vivo.
References:  55
Mediation of vasolidation in forearm vasculature.
Species:  Human
Tissue:  In vivo.
References:  19
Mediation of normal vasomotor responses in resistance and epicardial coronary vessels under basal and flow-stimulated conditions in coronary circulation.
Species:  Human
Tissue:  In vivo.
References:  36
Blockade of the B2 receptor prevents tissue swelling and inflammation in peptidoglycan-induced arthritis in the Lewis rat.
Species:  Rat
Tissue:  In vivo.
References:  78
B2 receptor ablated mice display reversal of the increased vascular permeability in a mouse model of hereditary angiodema.
Species:  Mouse
Tissue:  In vivo.
References:  38
Depolarization of a ventral root.
Species:  Rat
Tissue:  Peripheral nerve and spinal cord.
References:  23
Modulation of acute vascular pain and induced hyperalgesia.
Species:  Rat
Tissue:  In vivo.
References:  73
Involvement in vacoconstriction and tachycardia.
Species:  Rat
Tissue:  In vivo.
References:  18
Modulation of smooth muscle cell contraction.
Species:  Human
Tissue:  Isolated human umbilical vein.
References:  53
Physiological Consequences of Altering Gene Expression
B2 receptor knockout mice display an enhanced reponse to exogenous arginine-vasopressin.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  1
Bradykinin fails to produce responses in pharmacological preparations from ileum, uterus, and the superior cervical ganglia from B1 receptor knockout mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  8
Mice lacking both the B1 and B2 receptor are normotensive and protected from endotoxin- induced hypotension when compared to the wild type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  14
Transgenic mice overexpressing the B2 receptor are hypotensive and hyper-responsive to exogenous bradykinin.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  79
Mice lacking the B2 receptor display hypertension when subjected to a high-salt diet, when compared to the wild type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  2,15,77
B2 receptor knockout mice display an enhanced reponse to exogenous angiotensin II when compared to the wild type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  16
B2 receptor knockout mice are prone to renal dysplasia when compared to the wild type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  26
B2 receptor knockout mice display reduced glomerular capillary surface area when compared to the wild type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  71
B2 receptor knockout mice display decreased renin and cyclooxygenase (COX)-2 expression in the kidney when compared to the wild type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  43
B2 receptor knockout mice display insulin resistance when compared to the wild type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  25
B2 receptor knockout mice display increased renal fibrosis when compared to the wild type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  72
B2 receptor knockout mice are refractory to ischemic preconditioning when compared to the wild type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  84
B2 receptor knockout mice display reversal of the increased vascular permeability in a mouse model of hereditary angiodema.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  38
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Bdkrb2tm1Jfh|Ins2+|Ins2Akita Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
B6.129S7-Ins2 Bdkrb2
MGI:102845  MGI:96573  MP:0000488 abnormal intestinal epithelium morphology PMID: 16604193 
Bdkrb2tm1Jfh Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
B6.129S7-Bdkrb2
MGI:102845  MP:0002135 abnormal kidney morphology PMID: 17452647 
Bdkrb2/Bdkrb1tm1Mki Bdkrb2/Bdkrb1tm1Mki/Bdkrb2/Bdkrb1tm1Mki
involves: C57BL/6J
MGI:102845  MP:0002135 abnormal kidney morphology PMID: 17452647 
Acetm4Keb|Bdkrb2tm1Jfh Acetm4Keb/Acetm4Keb,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
MGI:102845  MGI:87874  MP:0000530 abnormal kidney vasculature morphology PMID: 12637363 
Bdkrb2tm1Jfh|Ins2+|Ins2Akita Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
B6.129S7-Ins2 Bdkrb2
MGI:102845  MGI:96573  MP:0002786 abnormal Leydig cell morphology PMID: 16604193 
Bdkrb2tm1Jfh Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
B6.129S7-Bdkrb2
MGI:102845  MP:0002786 abnormal Leydig cell morphology PMID: 16604193 
Bdkrb2tm1Jfh|Ins2+|Ins2Akita Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
B6.129S7-Ins2 Bdkrb2
MGI:102845  MGI:96573  MP:0006036 abnormal mitochondrial physiology PMID: 16604193 
Bdkrb2tm1Jfh Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
B6.129S7-Bdkrb2
MGI:102845  MP:0006036 abnormal mitochondrial physiology PMID: 16604193 
Bdkrb2tm1Jfh Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
B6.129S7-Bdkrb2
MGI:102845  MP:0004756 abnormal proximal convoluted tubule morphology PMID: 17452647 
Bdkrb2/Bdkrb1tm1Mki Bdkrb2/Bdkrb1tm1Mki/Bdkrb2/Bdkrb1tm1Mki
involves: C57BL/6J
MGI:102845  MP:0004756 abnormal proximal convoluted tubule morphology PMID: 17452647 
Acetm4Keb|Bdkrb2tm1Jfh Acetm4Keb/Acetm4Keb,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
MGI:102845  MGI:87874  MP:0003638 abnormal response/metabolism to endogenous compounds PMID: 12637363 
Bdkrb2tm1Jfh|Ins2+|Ins2Akita Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
B6.129S7-Ins2 Bdkrb2
MGI:102845  MGI:96573  MP:0002216 abnormal seminiferous tubule morphology PMID: 16604193 
Bdkrb2tm1Jfh|Ins2+|Ins2Akita Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
B6.129S7-Ins2 Bdkrb2
MGI:102845  MGI:96573  MP:0006378 abnormal spermatogonia morphology PMID: 16604193 
Bdkrb2tm1Jfh|Ins2+|Ins2Akita Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
B6.129S7-Ins2 Bdkrb2
MGI:102845  MGI:96573  MP:0000414 alopecia PMID: 16604193 
Bdkrb2tm1Jfh Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
B6.129S7-Bdkrb2
MGI:102845  MP:0005566 decreased blood urea nitrogen level PMID: 17452647 
Bdkrb2/Bdkrb1tm1Mki Bdkrb2/Bdkrb1tm1Mki/Bdkrb2/Bdkrb1tm1Mki
involves: C57BL/6J
MGI:102845  MP:0005566 decreased blood urea nitrogen level PMID: 17452647 
Bdkrb2tm1Jfh|Ins2+|Ins2Akita Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
B6.129S7-Ins2 Bdkrb2
MGI:102845  MGI:96573  MP:0010121 decreased bone mineral density PMID: 16604193 
Bdkrb2tm1Jfh Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
B6.129S7-Bdkrb2
MGI:102845  MP:0010121 decreased bone mineral density PMID: 16604193 
Bdkrb1tm2Bdr|Bdkrb2tm1Jfh Bdkrb1tm2Bdr/Bdkrb1tm2Bdr,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
involves: 129S7/SvEvBrd * C57BL/6
MGI:102845  MGI:88144  MP:0005333 decreased heart rate PMID: 16497152 
Acetm4Keb|Bdkrb2tm1Jfh Acetm4Keb/Acetm4Keb,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
MGI:102845  MGI:87874  MP:0000208 decreased hematocrit PMID: 12637363 
Acetm4Keb|Bdkrb2tm1Jfh Acetm4Keb/Acetm4Keb,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
MGI:102845  MGI:87874  MP:0003918 decreased kidney weight PMID: 12637363 
Bdkrb1tm2Bdr|Bdkrb2tm1Jfh Bdkrb1tm2Bdr/Bdkrb1tm2Bdr,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
involves: 129S7/SvEvBrd * C57BL/6
MGI:102845  MGI:88144  MP:0008874 decreased physiological sensitivity to xenobiotic PMID: 16497152 
Bdkrb2tm1Jfh|Ins2+|Ins2Akita Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
B6.129S7-Ins2 Bdkrb2
MGI:102845  MGI:96573  MP:0008844 decreased subcutaneous adipose tissue amount PMID: 16604193 
Bdkrb1tm2Bdr|Bdkrb2tm1Jfh Bdkrb1tm2Bdr/Bdkrb1tm2Bdr,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
involves: 129S7/SvEvBrd * C57BL/6
MGI:102845  MGI:88144  MP:0008734 decreased susceptibility to endotoxin shock PMID: 16497152 
Acetm4Keb|Bdkrb2tm1Jfh Acetm4Keb/Acetm4Keb,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
MGI:102845  MGI:87874  MP:0006264 decreased systemic arterial systolic blood pressure PMID: 12637363 
Acetm4Keb|Bdkrb2tm1Jfh Acetm4Keb/Acetm4Keb,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
MGI:102845  MGI:87874  MP:0002988 decreased urine osmolality PMID: 12637363 
Bdkrb2tm1Jfh Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
B6.129S7-Bdkrb2
MGI:102845  MP:0005565 increased blood urea nitrogen level PMID: 17452647 
Bdkrb2/Bdkrb1tm1Mki Bdkrb2/Bdkrb1tm1Mki/Bdkrb2/Bdkrb1tm1Mki
involves: C57BL/6J
MGI:102845  MP:0005565 increased blood urea nitrogen level PMID: 17452647 
Bdkrb2tm1Jfh Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
B6.129S7-Bdkrb2
MGI:102845  MP:0005553 increased circulating creatinine level PMID: 17452647 
Bdkrb2/Bdkrb1tm1Mki Bdkrb2/Bdkrb1tm1Mki/Bdkrb2/Bdkrb1tm1Mki
involves: C57BL/6J
MGI:102845  MP:0005553 increased circulating creatinine level PMID: 17452647 
Bdkrb2tm1Jfh Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
B6.129S7-Bdkrb2
MGI:102845  MP:0009763 increased sensitivity to induced morbidity/mortality PMID: 17452647 
Bdkrb2/Bdkrb1tm1Mki Bdkrb2/Bdkrb1tm1Mki/Bdkrb2/Bdkrb1tm1Mki
involves: C57BL/6J
MGI:102845  MP:0009763 increased sensitivity to induced morbidity/mortality PMID: 17452647 
Acetm4Keb|Bdkrb2tm1Jfh Acetm4Keb/Acetm4Keb,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
MGI:102845  MGI:87874  MP:0003675 kidney cysts PMID: 12637363 
Bdkrb2tm1Jfh|Ins2+|Ins2Akita Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
B6.129S7-Ins2 Bdkrb2
MGI:102845  MGI:96573  MP:0000160 kyphosis PMID: 16604193 
Bdkrb2tm1Jfh Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
involves: 129S7/SvEvBrd * C57BL/6
MGI:102845  MP:0002169 no abnormal phenotype detected PMID: 7775424 
Bdkrb2tm1Jfh|Serping1Gt1Aed Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Serping1Gt1Aed/Serping1Gt1Aed
involves: 129S5/SvEvBrd * C57BL/6
MGI:102845  MGI:894696  MP:0002169 no abnormal phenotype detected PMID: 11956243 
Bdkrb2tm1Jfh|Ins2+|Ins2Akita Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
B6.129S7-Ins2 Bdkrb2
MGI:102845  MGI:96573  MP:0002083 premature death PMID: 16604193 
Bdkrb2tm1Jfh Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
B6.129S7-Bdkrb2
MGI:102845  MP:0002083 premature death PMID: 16604193 
Acetm4Keb|Bdkrb2tm1Jfh Acetm4Keb/Acetm4Keb,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
MGI:102845  MGI:87874  MP:0001864 vasculitis PMID: 12637363 
Biologically Significant Variants
Type:  Single nucleotide polymorphisms
Species:  Human
Description:  The B2 C-58T polymorphism has been linked with insulin resistance.
References:  29
Type:  Insertion/deletion
Species:  Human
Description:  The -/- genotype of the B2 receptor gene exon 1 insertion/deletion polymorphism predicts an increased function of the B1 receptor.
References:  42
Type:  Single nucleotide polymorphisms, insertion/deletions
Species:  Human
Description:  Several B2 polymorphisms (21 +9/-9 Exon 1, -58C/T have been associated with cardiovascular disease.
References:  9,56
Type:  Insertion/deletion
Species:  Human
Description:  The B2 receptor 21 +9/-9 polymorphism has been linked with renal disease.
References:  52
Type:  Single nucleotide polymorphisms, insertion/deletions
Species:  Human
Description:  The B2 receptor polymorphism -58 T/C has been associated with airway disease.
References:  45
General Comments
B1 and B2 receptors are overexpressed in the hippocampus of humans with temporal lobe epilepsy [59].

References

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Joseph Coulson, Alexander Faussner, Fredrik Leeb-Lundberg, Francois Marceau, Werner Muller-Esterl, Doug Pettibone, Bruce Zuraw.
Bradykinin receptors: B2 receptor. Last modified on 03/02/2017. Accessed on 23/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=42.