K<sub>2P</sub>6.1 | Two P domain potassium channels | IUPHAR/BPS Guide to PHARMACOLOGY

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K2P6.1

Target not currently curated in GtoImmuPdb

Target id: 518

Nomenclature: K2P6.1

Abbreviated Name: TWIK2

Family: Two P domain potassium channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 2 313 19q13.1 KCNK6 potassium two pore domain channel subfamily K member 6 1,3
Mouse 4 2 313 7 B1 Kcnk6 potassium inwardly-rectifying channel
Rat 4 2 313 1q21 Kcnk6 potassium two pore domain channel subfamily K member 6
Previous and Unofficial Names
TOSS | potassium channel subfamily K member 6 (TWIK-2) | potassium channel, two pore domain subfamily K, member 6 | potassium inwardly-rectifying channel
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Functional Characteristics
Unknown

Download all structure-activity data for this target as a CSV file

Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Parameter Concentration range (M) Holding voltage (mV) Reference
quinidine Rn - - pIC50 < 1x10-4 - 2
pIC50 Conc range: < 1x10-4 M [2]
Ba2+ Rn - - pIC50 1x10-5 - 1x10-4 - 2
pIC50 Conc range: 1x10-5 - 1x10-4 M [2]
Tissue Distribution
Pancreas, placenta and heart
Species:  Human
Technique:  Northern Blot
References:  3
Liver
Species:  Mouse
Technique:  Northern Blot
References:  3
General Comments
‘Activation’ and ‘deactivation’ with voltage steps appear to be instantaneous. Displays time-dependent inactivation at depolarized potentials [2]. The rat variant has been reported to be widely expressed (including brain, lung, kidney, liver, spleen, heart, oesophagus, stomach, colon, skeletal muscle).

References

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1. Gray AT, Kindler CH, Sampson ER, Yost CS. (1999) Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping. Cytogenet. Cell Genet., 84 (3-4): 190-1. [PMID:10393428]

2. Patel AJ, Maingret F, Magnone V, Fosset M, Lazdunski M, Honoré E. (2000) TWIK-2, an inactivating 2P domain K+ channel. J. Biol. Chem., 275 (37): 28722-30. [PMID:10887187]

3. Pountney DJ, Gulkarov I, Vega-Saenz de Miera E, Holmes D, Saganich M, Rudy B, Artman M, Coetzee WA. (1999) Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit. FEBS Lett., 450 (3): 191-6. [PMID:10359073]

Contributors

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How to cite this page

Douglas A. Bayliss, Gábor Czirják, Péter Enyedi, Steve A.N. Goldstein, Florian Lesage, Daniel L. Minor, Jr., Leigh D. Plant, Francisco Sepúlveda, Brenda T. Winn.
Two P domain potassium channels: K2P6.1. Last modified on 14/03/2019. Accessed on 24/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=518.