K<sub>2P</sub>6.1 | Two P domain potassium channels | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 518

Nomenclature: K2P6.1

Abbreviated Name: TWIK2

Family: Two P domain potassium channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 2 313 19q13.1 KCNK6 potassium two pore domain channel subfamily K member 6 1,3
Mouse 4 2 313 7 B1 Kcnk6 potassium inwardly-rectifying channel
Rat 4 2 313 1q21 Kcnk6 potassium two pore domain channel subfamily K member 6
Previous and Unofficial Names
TOSS | potassium channel subfamily K member 6 (TWIK-2) | potassium channel, two pore domain subfamily K, member 6 | potassium inwardly-rectifying channel
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Functional Characteristics

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Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Parameter Concentration range (M) Holding voltage (mV) Reference
quinidine Rn - - pIC50 < 1x10-4 - 2
pIC50 Conc range: < 1x10-4 M [2]
Ba2+ Rn - - pIC50 1x10-5 - 1x10-4 - 2
pIC50 Conc range: 1x10-5 - 1x10-4 M [2]
Tissue Distribution
Pancreas, placenta and heart
Species:  Human
Technique:  Northern Blot
References:  3
Species:  Mouse
Technique:  Northern Blot
References:  3
General Comments
‘Activation’ and ‘deactivation’ with voltage steps appear to be instantaneous. Displays time-dependent inactivation at depolarized potentials [2]. The rat variant has been reported to be widely expressed (including brain, lung, kidney, liver, spleen, heart, oesophagus, stomach, colon, skeletal muscle).


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1. Gray AT, Kindler CH, Sampson ER, Yost CS. (1999) Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping. Cytogenet. Cell Genet., 84 (3-4): 190-1. [PMID:10393428]

2. Patel AJ, Maingret F, Magnone V, Fosset M, Lazdunski M, Honoré E. (2000) TWIK-2, an inactivating 2P domain K+ channel. J. Biol. Chem., 275 (37): 28722-30. [PMID:10887187]

3. Pountney DJ, Gulkarov I, Vega-Saenz de Miera E, Holmes D, Saganich M, Rudy B, Artman M, Coetzee WA. (1999) Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit. FEBS Lett., 450 (3): 191-6. [PMID:10359073]


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How to cite this page

Douglas A. Bayliss, Gábor Czirják, Péter Enyedi, Steve A.N. Goldstein, Florian Lesage, Daniel L. Minor, Jr., Leigh D. Plant, Francisco Sepúlveda, Brenda T. Winn.
Two P domain potassium channels: K2P6.1. Last modified on 14/03/2019. Accessed on 24/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=518.