K<sub>2P</sub>12.1 | Two P domain potassium channels | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 522

Nomenclature: K2P12.1

Abbreviated Name: THIK2

Family: Two P domain potassium channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 2 430 2p22-p21 KCNK12 potassium two pore domain channel subfamily K member 12 5
Mouse 4 2 430 17 E4 Kcnk12 potassium channel
Rat 4 2 430 6q12 Kcnk12 potassium two pore domain channel subfamily K member 12
Previous and Unofficial Names
THIK-2 | tandem pore domain halothane-inhibited potassium channel 2 | tandem pore domain potassium channel THIK-2 | mntk1 | potassium channel, two pore domain subfamily K, member 12 | potassium channel
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Associated Proteins
Heteromeric Pore-forming Subunits
Name References
K2P13.1 1
Auxiliary Subunits
Name References
Not determined
Other Associated Proteins
Name References
Not determined
Associated Protein Comments
Heteromultimers shown to form in vivo: Heterodimerization of K2P12 and K2P13 was recently reported in a heterologous expression system [1].

Protein-protein interactions: An N-terminal endoplasmic retention signal has been reported [2,6] but no protein partners have been identified.
Functional Characteristics
Does not function as a homodimer [5] but can form a functional heterodimer with K2P13 [1].

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Parameter Concentration range (M) Holding voltage (mV) Reference
halothane Hs - - - - - 1
Tissue Distribution
Kidney (proximal and distal nephron)
Expression level:  High
Species:  Human
Technique:  RT-PCR
References:  7
Kidney (proximal and distal nephron)
Expression level:  High
Species:  Mouse
Technique:  Immunohistochemistry and in situ hybridisation.
References:  7
Kidney (proximal and distal nephron)
Expression level:  High
Species:  Rat
Technique:  Immunohistochemistry and in situ hybridisation.
References:  7
Tissue Distribution Comments
Expression has also been reported in brain, heart, lung, kidney, liver, small intestine, colon, pancreas, prostate, placenta, spleen, thymus, and ovary.
Gene Expression and Pathophysiology Comments
High expression K2P12 is associated with resistance of lymphomas/leukemias to antitumor γδ T-cell cytotoxicity [3]. Elevated expression of K2P12 was found to be associated with poor ‘progression-free survival’ in B-cell lymphoma [4].


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1. Blin S, Chatelain FC, Feliciangeli S, Kang D, Lesage F, Bichet D. (2014) Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels. J. Biol. Chem., 289 (41): 28202-12. [PMID:25148687]

2. Chatelain FC, Bichet D, Feliciangeli S, Larroque MM, Braud VM, Douguet D, Lesage F. (2013) Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane. J. Biol. Chem., 288 (49): 35081-92. [PMID:24163367]

3. Gomes AQ, Correia DV, Grosso AR, Lança T, Ferreira C, Lacerda JF, Barata JT, Silva MG, Silva-Santos B. (2010) Identification of a panel of ten cell surface protein antigens associated with immunotargeting of leukemias and lymphomas by peripheral blood gammadelta T cells. Haematologica, 95 (8): 1397-404. [PMID:20220060]

4. Kim SJ, Sohn I, Do IG, Jung SH, Ko YH, Yoo HY, Paik S, Kim WS. (2014) Gene expression profiles for the prediction of progression-free survival in diffuse large B cell lymphoma: results of a DASL assay. Ann. Hematol., 93 (3): 437-47. [PMID:23975159]

5. Rajan S, Wischmeyer E, Karschin C, Preisig-Müller R, Grzeschik KH, Daut J, Karschin A, Derst C. (2001) THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels. J. Biol. Chem., 276 (10): 7302-11. [PMID:11060316]

6. Renigunta V, Zou X, Kling S, Schlichthörl G, Daut J. (2014) Breaking the silence: functional expression of the two-pore-domain potassium channel THIK-2. Pflugers Arch., 466 (9): 1735-45. [PMID:24297522]

7. Theilig F, Goranova I, Hirsch JR, Wieske M, Unsal S, Bachmann S, Veh RW, Derst C. (2008) Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney. Cell. Physiol. Biochem., 21 (1-3): 63-74. [PMID:18209473]


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How to cite this page

Douglas A. Bayliss, Gábor Czirják, Péter Enyedi, Steve A.N. Goldstein, Florian Lesage, Daniel L. Minor, Jr., Leigh D. Plant, Francisco Sepúlveda, Brenda T. Winn.
Two P domain potassium channels: K2P12.1. Last modified on 14/03/2019. Accessed on 24/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=522.