Target id: 527

Nomenclature: K2P18.1

Family: Two P domain potassium channels

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for K2P18.1 in GtoImmuPdb

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 2 384 10q25.3 KCNK18 potassium two pore domain channel subfamily K member 18 1
Mouse 4 2 394 19 D3 Kcnk18 potassium channel
Rat 4 2 405 1q55 Kcnk18 potassium two pore domain channel subfamily K member 18
Previous and Unofficial Names
TRESK-1/TRESK-2 | TRIK | TWIK related spinal cord K+ channel | tandem-pore K+ (K(2P)) channel | two-pore-domain potassium channel TRESK | potassium channel, two pore domain subfamily K, member 18
Database Links
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Functional Characteristics
Background current

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
arachidonic acid Hs - - - - - 1
studied at 10-50 µM [1]


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1. Sano Y, Inamura K, Miyake A, Mochizuki S, Kitada C, Yokoi H, Nozawa K, Okada H, Matsushime H, Furuichi K. (2003) A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord. J. Biol. Chem.278 (30): 27406-12. [PMID:12754259]


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How to cite this page

Leigh D. Plant, Douglas A. Bayliss, Daniel L. Minor, Jr., Gábor Czirják, Péter Enyedi, Florian Lesage, Francisco Sepúlveda, Steve A.N. Goldstein.
Two P domain potassium channels: K2P18.1. Last modified on 09/03/2017. Accessed on 25/02/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=527.