COUP-TF1

Nomenclature: COUP-TF1

Systematic Nomenclature: NR2F1

Family: 2F. COUP-TF-like receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species AA Chromosomal Location Gene Symbol Gene Name Reference
Human 423 5q14 NR2F1 nuclear receptor subfamily 2, group F, member 1 21
Mouse 420 13 45.0 cM Nr2f1 nuclear receptor subfamily 2, group F, member 1 14
Rat 419 2q11 Nr2f1 nuclear receptor subfamily 2, group F, member 1 2
Previous and Unofficial Names
EAR-3
TCFCOUP1
COUP-TFI
COUPα
EAR3
SVP44
ERBAL3
TFCOUP1
LOC360330
Nr2f1_predicted
nuclear receptor subfamily 2, group F, member 1
nuclear receptor subfamily 2, group F, member 1 (predicted)
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
NURSA Receptor
OMIM
PharmGKB Gene
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniProtKB
Wikipedia
Natural/Endogenous Ligands
Comments: Orphan
DNA Binding
Structure:  Homodimer, Heterodimer
HRE core sequence:  AGGTCA n AGGTCA
Response element:  DR1, DR3, DR4, DR5, Palindrome, Other - see comments
DNA Binding Comments
Heterodimerization with RXR in solution is still a controversial issue. However, COUP-TFs readily form DNA-binding heterodimers with RXR. COUP-TFI is able to heterodimerize with COUP-TFII. Systematic comparison of the relative affinities of COUP-TFs for the various elements reveal that DR1 is the preferred element and then DR6, DR4, DR8, DR0 and DR11. Palindromic and inverted repeats are also recognised but with a lower affinity. In contrast, monomeric elements are not efficiently recognised by COUP-TFs. It has been demonstrated that COUP-TFs repress the hormonal induction of target genes by PPAR, VDR, TR, and RAR in transient transfection assays through direct competition with VDR, TR, and RAR for the available binding sites.
Co-binding Partners
Name Interaction Effect Reference
Retinoid X receptor-β Physical, Functional COUP-TFs are able to sequester the common heterodimerization partner RXR and reduce the available concentrations of RXR. The loss of RXR indirectly decreases the DNA-binding affinity of TR, VDR, RAR, and PPAR and thereby interferes with the potential of this subgroup of receptors to transactivate their target genes. 3-4,6,20
Hepatocyte nuclear factor-4-α Physical, Functional COUP-TF interact both functionally and physically with the NRs HNF4. COUP-TFs have been shown to inhibit the transactivation of HNF4 due to mutually exclusive binding to the promoter of many genes. In addition, COUP-TF activates transcription through protein-protein interaction with DNA-bound factor, such as with HNF-4 in the HNF-1a gene promoter. Similar mechanism are observed for other transcription factor (Sp1). 7,16,19
Thyroid hormone receptor-α Physical, Functional COUP-TFs:TR heterodimerization interfere with TR dependent transcriptional regulation. 3,8
Retinoic acid receptor-α Physical, Functional COUP-TFs:RAR heterodimerization interfere with RAR dependent transcriptional regulation. 3,8
Estrogen receptor-α Physical, Functional the formation of a tight ERa-COUP-TFI intermediate complex through COUP-TFI DBD and ER LBD resulted in an increased recruitment of ERK2/p42 MAPK, phosphorylation of the hERa on Ser 118 and enhanced its transcriptional activity. In addition, COUP-TF has been shown to antagonize ER activation of the lactoferrin and oxytocin promoters by binding to a binding site that overlaps with the estrogen response element. 10-11
Main Co-regulators
Name Activity Specific Ligand dependent AF-2 dependent Comments References
NCOR1 Co-repressor No No No 18
NCOR2 Co-repressor No No No 18
BCL11A Co-repressor Yes No Yes transcriptional repression mediated by COUP-TF acting through CTIP1 did not appear to involve recruitment of a trichostatin A-sensitive histone deacetylase to the template, suggesting that this repression pathway may be distinct from that utilized by several other nuclear receptors. 1
BCL11B Co-repressor No No Yes transcriptional repression mediated by COUP-TF acting through CTIP1 did not appear to involve recruitment of a trichostatin A-sensitive histone deacetylase to the template, suggesting that this repression pathway may be distinct from that utilized by several other nuclear receptors. 1
NCOA1 Co-activator No No Yes 19
CREBBP Co-activator No No Yes COUP-TFI also interacts with EP300 also known as p300. 13
Main Target Genes
Name Species Effect Technique Comments References
CYP3A1 Human Repressed Transient transfection, EMSA, Other COUP-TFs repressed the CYP3A1 gene expression by interacting with HNF4 (see in all species) 12
Nr4a1 Rat Activated Transient transfection, EMSA, Other COUP TFI positively regulates the NGFI-A gene via aprotein-protein interaction with DNA bound Sp1. 13
PEPCK Human Activated Transient transfection, EMSA COUP-TF binds to the AF1 element and function as accessory factors for the glucocorticoid response of the PEPCK gene ( activated in all species) 5,17
Transferrin Human Both Transient transfection, EMSA, Other COUP-TF1 alone or in combination with HNF4 activates or repress Transferrin gene expression respectively. 16
MHC Class I Mouse Repressed Transient transfection, EMSA COUP-TFs directly inhibits MHC Class I expression via interaction with the R2 promoter element and recruitment of the NCoR and HDACs. 9
Tissue Distribution Comments
In human COUP-TFI is expressed as two transcripts of 4.6 and 4.8 kb that show a broad expression pattern. In mice, COUP-TFI expression was first detected at 7.5 dpc, peaked at 14-15 days dpc and strongly declined before birth when organogenesis stops. At 8.5 dpc COUP-TFI is expressed in specific regions of the rostral brain, in stripes in the presumptive hindbrain as well as in the anterior somites. Later on, it exhibits a more complex expression pattern in CNS which is clearly different from the one of COUP-TFII. COUP-TFI is expressed throughout the neural tube with a small increased level in motoneurons. The expression appears also restricted in other organs and is always weaker than the one of COUP-TFII. COUP-TFI is found at high levels in the tongue, the follicles of the vibrissae, the cochlea and in the nasal septum stroma. In organs that requires mesenchymal and epithelial interactions, COUP-TFI is expressed in the mesenchymal cells, but not in the terminally differentiated epithelium. In adult, the expression is strongly reduced and COUP-TFI was found in the rostral and caudal part of the mouse brain, in particular in the supraoptic nucleus [1,13-14].
Physiological Consequences of Altering Gene Expression
COUP-TFI knock-out animals die at birth from starvation and dehydratation.
Species:  Mouse
Tissue: 
Technique:  Gene knockout
References:  15,22-24
Physiological Consequences of Altering Gene Expression Comments
These animals exhibit defects in morphogenesis of the ninth cranial ganglion and nerve resulting from an excess cell death in the ganglionic precursor cells. In addition axonal guidance and arborization defects were noticed in several regions. This results in a fewer number of cells in the ninth ganglia and abnormal nerve projections toward the hindbrain. Since the ninth ganglia supplies sensory and motor innervation to the pharynx and root of the tongue as well as to the ear and soft palate this may explain the inability of the mutant animals to obtain exogenous nutriments and there death by starvation and dehydratation. In addition COUP-TFI mutants have axon guidance defect which results in the thanlamocortical axon could not reach cortex to innervate neurons in layer IV and to maintain layer IV neuron survival. Furthermore, COUP-TFI mutants has brain regionalization defect. COUP-TFI is one of the regulatory genes that control the expression of genes important for brain regionalization. Finally, COUP-TFI is important for axon myelination. Without it oligodendrocytes can not differentiation properly.
Phenotypes, Alleles and Disease Models Mouse data from MGI

Show »

Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Nr2f1tm1Mist Nr2f1tm1Mist/Nr2f1tm1Mist
involves: 129S2/SvPas * C57BL/6J
MGI:1352451  MP:0008225 abnormal anterior commissure morphology PMID: 17021036 
Nr2f1tm1Mjts Nr2f1tm1Mjts/Nr2f1tm1Mjts
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352451  MP:0002961 abnormal axon guidance PMID: 9271116 
Nr2f1tm1Mist Nr2f1tm1Mist/Nr2f1tm1Mist
involves: 129S2/SvPas * C57BL/6J
MGI:1352451  MP:0002961 abnormal axon guidance PMID: 17021036 
Nr2f1tm1Mist Nr2f1tm1Mist/Nr2f1tm1Mist
involves: 129S2/SvPas * C57BL/6J
MGI:1352451  MP:0005404 abnormal axon morphology PMID: 17021036 
Nr2f1tm1Mist Nr2f1tm1Mist/Nr2f1tm1Mist
involves: 129S2/SvPas * C57BL/6J
MGI:1352451  MP:0002199 abnormal brain commissure morphology PMID: 17021036 
Nr2f1tm1Mjts Nr2f1tm1Mjts/Nr2f1tm1Mjts
involves: 129S7/SvEvBrd
MGI:1352451  MP:0000788 abnormal cerebral cortex morphology PMID: 10624948  11511537 
Nr2f1tm1Mist Nr2f1tm1Mist/Nr2f1tm1Mist
involves: 129S2/SvPas * C57BL/6J
MGI:1352451  MP:0000788 abnormal cerebral cortex morphology PMID: 17021036 
Nr2f1tm1Mist Nr2f1tm1Mist/Nr2f1tm1Mist
involves: 129S2/SvPas * C57BL/6J
MGI:1352451  MP:0004167 abnormal cingulate gyrus morphology PMID: 17021036 
Nr2f1tm1Mjts Nr2f1tm1Mjts/Nr2f1tm1Mjts
involves: 129S7/SvEvBrd
MGI:1352451  MP:0004589 abnormal cochlear hair cell development PMID: 16914494 
Nr2f1tm1Mjts Nr2f1tm1Mjts/Nr2f1tm1Mjts
involves: 129S7/SvEvBrd
MGI:1352451  MP:0003308 abnormal cochlear sensory epithelium morphology PMID: 16914494 
Nr2f1tm1Mist Nr2f1tm1Mist/Nr2f1tm1Mist
involves: 129S2/SvPas * C57BL/6J
MGI:1352451  MP:0000780 abnormal corpus callosum morphology PMID: 17021036 
Nr2f1tm2.1Mjts|Nr2f2tm2.1Tsa|Tg(rx3-cre)1Mjam Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(rx3-cre)1Mjam/0
involves: 129S7/SvEvBrd
MGI:1352451  MGI:1352452  MGI:3665327  MP:0001286 abnormal eye development PMID: 20147377 
Nr2f1tm1Mjts Nr2f1tm1Mjts/Nr2f1tm1Mjts
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352451  MP:0001096 abnormal glossopharyngeal ganglion morphology PMID: 9271116 
Nr2f1tm1Mjts Nr2f1tm1Mjts/Nr2f1tm1Mjts
involves: 129S7/SvEvBrd
MGI:1352451  MP:0001963 abnormal hearing physiology PMID: 10624948 
Nr2f1tm1Mist Nr2f1tm1Mist/Nr2f1tm1Mist
involves: 129S2/SvPas * C57BL/6J
MGI:1352451  MP:0008221 abnormal hippocampal commissure morphology PMID: 17021036 
Nr2f1tm1Mist Nr2f1tm1Mist/Nr2f1tm1Mist
involves: 129S2/SvPas * C57BL/6J
MGI:1352451  MP:0002882 abnormal neuron morphology PMID: 17021036 
Nr2f1tm2.1Mjts|Nr2f2tm2.1Tsa|Tg(rx3-cre)1Mjam Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(rx3-cre)1Mjam/0
involves: 129S7/SvEvBrd
MGI:1352451  MGI:1352452  MGI:3665327  MP:0008259 abnormal optic disc morphology PMID: 20147377 
Nr2f1tm2.1Mjts|Nr2f2tm2.1Tsa|Tg(rx3-cre)1Mjam Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(rx3-cre)1Mjam/0
involves: 129S7/SvEvBrd
MGI:1352451  MGI:1352452  MGI:3665327  MP:0004268 abnormal optic stalk morphology PMID: 20147377 
Nr2f1tm1Mjts Nr2f1tm1Mjts/Nr2f1tm1Mjts
involves: 129S7/SvEvBrd
MGI:1352451  MP:0008304 abnormal organ of Corti supporting cell differentiation PMID: 16914494 
Nr2f1tm1Mjts Nr2f1tm1Mjts/Nr2f1tm1Mjts
involves: 129S7/SvEvBrd
MGI:1352451  MP:0004492 abnormal orientation of inner hair cell stereociliary bundles PMID: 16914494 
Nr2f1tm1Mjts Nr2f1tm1Mjts/Nr2f1tm1Mjts
involves: 129S7/SvEvBrd
MGI:1352451  MP:0004491 abnormal orientation of outer hair cell stereociliary bundles PMID: 16914494 
Nr2f1tm2.1Mjts|Nr2f2tm2.1Tsa|Tg(rx3-cre)1Mjam Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(rx3-cre)1Mjam/0
involves: 129S7/SvEvBrd
MGI:1352451  MGI:1352452  MGI:3665327  MP:0005201 abnormal retinal pigment epithelium morphology PMID: 20147377 
Nr2f1tm1Mjts Nr2f1tm1Mjts/Nr2f1tm1Mjts
involves: 129S7/SvEvBrd
MGI:1352451  MP:0000862 absent barrels in primary somatosensory cortex PMID: 10624948 
Nr2f1tm2.1Mjts|Nr2f2tm2.1Tsa|Tg(rx3-cre)1Mjam Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(rx3-cre)1Mjam/0
involves: 129S7/SvEvBrd
MGI:1352451  MGI:1352452  MGI:3665327  MP:0005262 coloboma PMID: 20147377 
Nr2f1+|Nr2f1tm2.1Mjts|Nr2f2tm2.1Tsa|Tg(rx3-cre)1Mjam Nr2f1tm2.1Mjts/Nr2f1+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(rx3-cre)1Mjam/0
involves: 129S7/SvEvBrd
MGI:1352451  MGI:1352452  MGI:3665327  MP:0005262 coloboma PMID: 20147377 
Nr2f1tm2.1Mjts|Nr2f2+|Nr2f2tm2.1Tsa|Tg(rx3-cre)1Mjam Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts,Nr2f2tm2.1Tsa/Nr2f2+,Tg(rx3-cre)1Mjam/0
involves: 129S7/SvEvBrd
MGI:1352451  MGI:1352452  MGI:3665327  MP:0005262 coloboma PMID: 20147377 
Nr2f1tm1Mjts Nr2f1tm1Mjts/Nr2f1tm1Mjts
involves: 129S7/SvEvBrd
MGI:1352451  MP:0004407 increased cochlear hair cell number PMID: 16914494 
Nr2f1tm1Mjts Nr2f1tm1Mjts/Nr2f1tm1Mjts
involves: 129S7/SvEvBrd
MGI:1352451  MP:0004395 increased cochlear inner hair cell number PMID: 16914494 
Nr2f1tm1Mjts Nr2f1tm1Mjts/Nr2f1tm1Mjts
involves: 129S7/SvEvBrd
MGI:1352451  MP:0004401 increased cochlear outer hair cell number PMID: 16914494 
Nr2f1tm1Mjts Nr2f1tm1Mjts/Nr2f1tm1Mjts
involves: 129S7/SvEvBrd
MGI:1352451  MP:0004840 increased Deiters cell number PMID: 16914494 
Nr2f1tm2.1Mjts|Nr2f2tm2.1Tsa|Tg(rx3-cre)1Mjam Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(rx3-cre)1Mjam/0
involves: 129S7/SvEvBrd
MGI:1352451  MGI:1352452  MGI:3665327  MP:0001297 microphthalmia PMID: 20147377 
Nr2f1tm1Mjts Nr2f1tm1Mjts/Nr2f1tm1Mjts
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352451  MP:0002058 neonatal lethality PMID: 9271116 
Nr2f1tm1Mjts Nr2f1tm1Mjts/Nr2f1tm1Mjts
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352451  MP:0001437 no swallowing reflex PMID: 9271116 
Nr2f1tm1Mist Nr2f1tm1Mist/Nr2f1tm1Mist
involves: 129S2/SvPas * C57BL/6J
MGI:1352451  MP:0002081 perinatal lethality PMID: 17021036 
Nr2f1tm1Mjts Nr2f1tm1Mjts/Nr2f1tm1Mjts
involves: 129S7/SvEvBrd
MGI:1352451  MP:0008307 short scala media PMID: 16914494 

References

Show »

1. Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M. (2000) Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. J. Biol. Chem.275 (14): 10315-22. [PMID:10744719]

2. Connor H, Nornes H, Neuman T. (1995) Expression screening reveals an orphan receptor chick ovalbumin upstream promoter transcription factor I as a regulator of neurite/substrate-cell contacts and cell aggregation. J. Biol. Chem.270 (25): 15066-70. [PMID:7797489]

3. Cooney AJ, Leng X, Tsai SY, O'Malley BW, Tsai MJ. (1993) Multiple mechanisms of chicken ovalbumin upstream promoter transcription factor-dependent repression of transactivation by the vitamin D, thyroid hormone, and retinoic acid receptors. J. Biol. Chem.268 (6): 4152-60. [PMID:8382695]

4. Cooney AJ, Tsai SY, O'Malley BW, Tsai MJ. (1992) Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone, and retinoic acid receptors. Mol. Cell. Biol.12 (9): 4153-63. [PMID:1324415]

5. Hall RK, Sladek FM, Granner DK. (1995) The orphan receptors COUP-TF and HNF-4 serve as accessory factors required for induction of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids. Proc. Natl. Acad. Sci. U.S.A.92 (2): 412-6. [PMID:7831301]

6. Kliewer SA, Umesono K, Heyman RA, Mangelsdorf DJ, Dyck JA, Evans RM. (1992) Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling. Proc. Natl. Acad. Sci. U.S.A.89 (4): 1448-52. [PMID:1311101]

7. Ktistaki E, Talianidis I. (1997) Chicken ovalbumin upstream promoter transcription factors act as auxiliary cofactors for hepatocyte nuclear factor 4 and enhance hepatic gene expression. Mol. Cell. Biol.17 (5): 2790-7. [PMID:9111350]

8. Leng X, Cooney AJ, Tsai SY, Tsai MJ. (1996) Molecular mechanisms of COUP-TF-mediated transcriptional repression: evidence for transrepression and active repression. Mol. Cell. Biol.16 (5): 2332-40. [PMID:8628300]

9. Liu X, Ge R, Westmoreland S, Cooney AJ, Tsai SY, Tsai MJ, Ricciardi RP. (1994) Negative regulation by the R2 element of the MHC class I enhancer in adenovirus-12 transformed cells correlates with high levels of COUP-TF binding. Oncogene9 (8): 2183-90. [PMID:8036004]

10. Liu Y, Yang N, Teng CT. (1993) COUP-TF acts as a competitive repressor for estrogen receptor-mediated activation of the mouse lactoferrin gene. Mol. Cell. Biol.13 (3): 1836-46. [PMID:8441416]

11. Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F. (2002) Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK. EMBO J.21 (13): 3443-53. [PMID:12093745]

12. Ogino M, Nagata K, Miyata M, Yamazoe Y. (1999) Hepatocyte nuclear factor 4-mediated activation of rat CYP3A1 gene and its modes of modulation by apolipoprotein AI regulatory protein I and v-ErbA-related protein 3. Arch. Biochem. Biophys.362 (1): 32-7. [PMID:9917326]

13. Pipaón C, Tsai SY, Tsai MJ. (1999) COUP-TF upregulates NGFI-A gene expression through an Sp1 binding site. Mol. Cell. Biol.19 (4): 2734-45. [PMID:10082539]

14. Qiu Y, Cooney AJ, Kuratani S, DeMayo FJ, Tsai SY, Tsai MJ. (1994) Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon. Proc. Natl. Acad. Sci. U.S.A.91 (10): 4451-5. [PMID:8183930]

15. Qiu Y, Pereira FA, DeMayo FJ, Lydon JP, Tsai SY, Tsai MJ. (1997) Null mutation of mCOUP-TFI results in defects in morphogenesis of the glossopharyngeal ganglion, axonal projection, and arborization. Genes Dev.11 (15): 1925-37. [PMID:9271116]

16. Schaeffer E, Guillou F, Part D, Zakin MM. (1993) A different combination of transcription factors modulates the expression of the human transferrin promoter in liver and Sertoli cells. J. Biol. Chem.268 (31): 23399-408. [PMID:8226864]

17. Scott DK, Mitchell JA, Granner DK. (1996) The orphan receptor COUP-TF binds to a third glucocorticoid accessory factor element within the phosphoenolpyruvate carboxykinase gene promoter. J. Biol. Chem.271 (50): 31909-14. [PMID:8943235]

18. Shibata H, Nawaz Z, Tsai SY, O'Malley BW, Tsai MJ. (1997) Gene silencing by chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI) is mediated by transcriptional corepressors, nuclear receptor-corepressor (N-CoR) and silencing mediator for retinoic acid receptor and thyroid hormone receptor (SMRT). Mol. Endocrinol.11 (6): 714-24. [PMID:9171235]

19. Sugiyama T, Wang JC, Scott DK, Granner DK. (2000) Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene. J. Biol. Chem.275 (5): 3446-54. [PMID:10652338]

20. Tran P, Zhang XK, Salbert G, Hermann T, Lehmann JM, Pfahl M. (1992) COUP orphan receptors are negative regulators of retinoic acid response pathways. Mol. Cell. Biol.12 (10): 4666-76. [PMID:1328857]

21. Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, O'Malley BW. (1989) COUP transcription factor is a member of the steroid receptor superfamily. Nature340 (6229): 163-6. [PMID:2739739]

22. Yamaguchi H, Zhou C, Lin SC, Durand B, Tsai SY, Tsai MJ. (2004) The nuclear orphan receptor COUP-TFI is important for differentiation of oligodendrocytes. Dev. Biol.266 (2): 238-51. [PMID:14738874]

23. Zhou C, Qiu Y, Pereira FA, Crair MC, Tsai SY, Tsai MJ. (1999) The nuclear orphan receptor COUP-TFI is required for differentiation of subplate neurons and guidance of thalamocortical axons. Neuron24 (4): 847-59. [PMID:10624948]

24. Zhou C, Tsai SY, Tsai MJ. (2001) COUP-TFI: an intrinsic factor for early regionalization of the neocortex. Genes Dev.15 (16): 2054-9. [PMID:11511537]

How to cite this page

2F. COUP-TF-like receptors: COUP-TF1. Last modified on 13/12/2013. Accessed on 23/10/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=617.