Kidney-specific Na-K-Cl symporter

Target id: 968

Nomenclature: Kidney-specific Na-K-Cl symporter

Abbreviated Name: NKCC2

Systematic Nomenclature: SLC12A1

Family: SLC12 family of cation-coupled chloride transporters

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Kidney-specific Na-K-Cl symporter in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1099 15q15-q21 SLC12A1 solute carrier family 12 member 1
Mouse - 1095 2 61.23 cM Slc12a1 solute carrier family 12, member 1
Rat - 1095 3q36 Slc12a1 solute carrier family 12 member 1
Previous and Unofficial Names
BSC2 | Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 | NKCC2 | Solute carrier family 12 member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter) | urehr3 | solute carrier family 12 (sodium/potassium/chloride transporters), member 1 | solute carrier family 12 (sodium/potassium/chloride transporter), member 1
Database Links
Specialist databases
Bioparadigms SLC Tables SLC12A1 (Hs)
Other databases
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
Orphanet
UniProtKB
Wikipedia
Stoichiometry
1 Na+ : 1 K+ : 2 Cl- (in)

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
bumetanide Hs Inhibition 6.5 pIC50 2
pIC50 6.5 [2]
piretanide Hs Inhibition 6.0 pIC50 2
pIC50 6.0 [2]
furosemide Hs Inhibition 5.2 pIC50 2
pIC50 5.2 [2]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Bartter syndrome, antenatal, type 1
Synonyms: Antenatal Bartter syndrome [Orphanet: ORPHA93604]
Bartter disease [Disease Ontology: DOID:445]
Disease Ontology: DOID:445
OMIM: 601678
Orphanet: ORPHA93604
References:  1

References

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1. Adachi M, Asakura Y, Sato Y, Tajima T, Nakajima T, Yamamoto T, Fujieda K. (2007) Novel SLC12A1 (NKCC2) mutations in two families with Bartter syndrome type 1. Endocr. J.54 (6): 1003-7. [PMID:17998760]

2. Hannaert P, Alvarez-Guerra M, Pirot D, Nazaret C, Garay RP. (2002) Rat NKCC2/NKCC1 cotransporter selectivity for loop diuretic drugs. Naunyn Schmiedebergs Arch. Pharmacol.365 (3): 193-9. [PMID:11882915]

How to cite this page

SLC12 family of cation-coupled chloride transporters: Kidney-specific Na-K-Cl symporter. Last modified on 18/07/2014. Accessed on 20/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=968.