Kidney-specific Na-K-Cl symporter

Target id: 968

Nomenclature: Kidney-specific Na-K-Cl symporter

Abbreviated Name: NKCC2

Systematic Nomenclature: SLC12A1

Family: SLC12 family of cation-coupled chloride transporters

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Kidney-specific Na-K-Cl symporter in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1099 15q15-q21 SLC12A1 solute carrier family 12 member 1
Mouse - 1095 2 61.23 cM Slc12a1 solute carrier family 12, member 1
Rat - 1095 3q36 Slc12a1 solute carrier family 12 member 1
Previous and Unofficial Names
BSC2 | Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 | NKCC2 | Solute carrier family 12 member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter) | urehr3 | solute carrier family 12 (sodium/potassium/chloride transporters), member 1 | solute carrier family 12 (sodium/potassium/chloride transporter), member 1 | solute carrier family 12
Database Links
Specialist databases
Bioparadigms SLC Tables SLC12A1 (Hs)
Other databases
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
1 Na+ : 1 K+ : 2 Cl- (in)

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
bumetanide Hs Inhibition 6.5 pIC50 2
pIC50 6.5 [2]
piretanide Hs Inhibition 6.0 pIC50 2
pIC50 6.0 [2]
furosemide Hs Inhibition 5.2 pIC50 2
pIC50 5.2 [2]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Bartter syndrome, antenatal, type 1
Synonyms: Antenatal Bartter syndrome [Orphanet: ORPHA93604]
Bartter disease [Disease Ontology: DOID:445]
Disease Ontology: DOID:445
OMIM: 601678
Orphanet: ORPHA93604
References:  1


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1. Adachi M, Asakura Y, Sato Y, Tajima T, Nakajima T, Yamamoto T, Fujieda K. (2007) Novel SLC12A1 (NKCC2) mutations in two families with Bartter syndrome type 1. Endocr. J.54 (6): 1003-7. [PMID:17998760]

2. Hannaert P, Alvarez-Guerra M, Pirot D, Nazaret C, Garay RP. (2002) Rat NKCC2/NKCC1 cotransporter selectivity for loop diuretic drugs. Naunyn Schmiedebergs Arch. Pharmacol.365 (3): 193-9. [PMID:11882915]

How to cite this page

SLC12 family of cation-coupled chloride transporters: Kidney-specific Na-K-Cl symporter. Last modified on 18/07/2014. Accessed on 17/03/2018. IUPHAR/BPS Guide to PHARMACOLOGY,