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synPHARM

SynPharm is a database of ligand-responsive protein sequences, derived from interactions from the Guide to PHARMACOLOGY and using data from the Protein Data Bank.

'Bind sequences' are obtained by identifying key binding residues on target proteins interating with a ligand.

The sequences can be used to confer druggability to a synthetic protein, and each contain metrics such as atomic contact ratio, proportional length and residue distance matrices.

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Latest database release, version 2016.3

Our third database release of 2016, version 2016.3 was published on 21st July 2016. Follow the link below to the release blog for further details.

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Recent Publications

IUPHAR review article on melatonin receptors

Jockers R, Delagrange P, Dubocovich ML, Markus RP, Renault N, Tosini G, Cecon E, Zlotos DP. (2016) Br J Pharmacol. : doi: 10.1111/bph.13536 [Epub ahead of print].

IUPHAR review article on function and regulation of acid-sensing ion channels and the epithelial Na+ channel

Boscardin E, Alijevic O, Hummler E, Frateschi S, Kellenberger S. (2016) Br J Pharmacol. : doi: 10.1111/bph.13533 [Epub ahead of print].

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The Concise Guide to PHARMACOLOGY 2015/16

Concise Guide to Pharamcology 2015/16

A FREE publication snapshot created from the database summary pages.

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Please see the 4 minute introductory video on the Concise Guide:

IUPHAR Database

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The IUPHAR/BPS Guide to PHARMACOLOGY builds upon and replaces the original IUPHAR Committee on Receptor Nomenclature and Drug Classification Database (IUPHAR-DB)