Disease ID:232
Associated with:3 targets
1 immuno-relevant targets
5 immuno-relevant ligands


5-HT1A receptor
Comments:  Serotonin acting via 5-HT1A receptors plays a key role in the pathogenesis of experimental colitis
NK1 receptor
Role:  Colonic inflammation, colonic fibrosis, colitis induced transformation
References:  1-2,4-7


Ligand Approved Immuno References Clinical comments
triamcinolone  [  ( ]
Clinical Use: Triamcinolone is used for its antiinflammatory or immunosuppressive actions in many conditions. For example, oral triamcinolone is used to treat conditions such as allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, and breathing disorders. This drug is also used topically as an anti-inflammatory and anti-pruritic agent. Injectable forms of the drug may be used to reduce intra-articular joint pain, stiffness and swelling associated with rheumatoid and osteoarthritic arthritis, bursitis, epicondylitis, and tenosynovitis.
Immuno Disease Comments: Glucocorticoid drug used to treat many inflammatory condtions including colitis.
methylprednisolone  [  ( ]
Clinical Use: Methylprednisolone is used to treat numerous inflammatory conditions including arthritis, lupus, psoriasis, ulcerative colitis and allergic disorders. The drug is also used to treat glucocorticoid-responsive conditions of the skin, eyes, lungs, stomach, nervous system and blood cells, and some endocrine conditions.
Immuno Disease Comments: A corticosteroid used to treat colitis.
bihelical apoA-I mimetic peptide 5A
Immuno Disease Comments: Experimental compound with predicted application in colitis.
compound 24 [PMID: 26987013 ]
Immuno Disease Comments: Experimental compound with predicted application in inflammatory bowel disease.
Immuno Disease Comments: Probe compound for experimental use.


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1. Dai L, Perera DS, King DW, Southwell BR, Burcher E, Liu L. (2012) Hemokinin-1 stimulates prostaglandin E₂ production in human colon through activation of cyclooxygenase-2 and inhibition of 15-hydroxyprostaglandin dehydrogenase. J. Pharmacol. Exp. Ther., 340 (1): 27-36. [PMID:21957267]

2. Engel MA, Becker C, Reeh PW, Neurath MF. (2011) Role of sensory neurons in colitis: increasing evidence for a neuroimmune link in the gut. Inflamm. Bowel Dis., 17 (4): 1030-3. [PMID:20722067]

3. Ghia JE, Li N, Wang H, Collins M, Deng Y, El-Sharkawy RT, Côté F, Mallet J, Khan WI. (2009) Serotonin has a key role in pathogenesis of experimental colitis. Gastroenterology, 137 (5): 1649-60. [PMID:19706294]

4. Gillespie E, Leeman SE, Watts LA, Coukos JA, O'Brien MJ, Cerda SR, Farraye FA, Stucchi AF, Becker JM. (2011) Truncated neurokinin-1 receptor is increased in colonic epithelial cells from patients with colitis-associated cancer. Proc. Natl. Acad. Sci. U.S.A., 108 (42): 17420-5. [PMID:21969570]

5. Koon HW, Shih D, Karagiannides I, Zhao D, Fazelbhoy Z, Hing T, Xu H, Lu B, Gerard N, Pothoulakis C. (2010) Substance P modulates colitis-associated fibrosis. Am. J. Pathol., 177 (5): 2300-9. [PMID:20889569]

6. Liu L, Markus I, Saghire HE, Perera DS, King DW, Burcher E. (2011) Distinct differences in tachykinin gene expression in ulcerative colitis, Crohn's disease and diverticular disease: a role for hemokinin-1?. Neurogastroenterol. Motil., 23 (5): 475-83, e179-80. [PMID:21342363]

7. Pagán B, Isidro AA, Coppola D, Chen Z, Ren Y, Wu J, Appleyard CB. (2010) Effect of a neurokinin-1 receptor antagonist in a rat model of colitis-associated colon cancer. Anticancer Res., 30 (9): 3345-53. [PMID:20944107]