NLRP6 | NOD-like receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

NLRP6

Target id: 1773

Nomenclature: NLRP6

Family: NOD-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     NLRP6 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 892 11p15.5 NLRP6 NLR family pyrin domain containing 6
Mouse - 869 7 86.14 cM Nlrp6 NLR family, pyrin domain containing 6
Rat - 880 1q41 Nlrp6 NLR family, pyrin domain containing 6
Previous and Unofficial Names
CLR11.4 | NALP6 | PAN3 | NACHT, leucine rich repeat and PYD containing 6 | dual angiotensin II/vasopressin receptor | NLR family, pyrin domain containing 6 | PYPAF5 | AVR | NAVR | NAVR/AVR | NLR family
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
NLRP6 is an intracellular pattern recognition receptor (PRR). It is a member of the NACHT, LRR and PYD domains-containing protein (NALP) subfamily of PRRs. The presence of NALPs in inflammasomes underlies their involvement in regulating proinflammatory caspases (esp. caspase 1) and NF-κB.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 5 GO processes
GO:0050727 regulation of inflammatory response ISS
click arrow to show/hide IEA associations
GO:0002862 negative regulation of inflammatory response to antigenic stimulus IEA
GO:0006954 inflammatory response IEA
GO:0034122 negative regulation of toll-like receptor signaling pathway IEA
GO:0045087 innate immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0050727 regulation of inflammatory response ISS
click arrow to show/hide IEA associations
GO:0002862 negative regulation of inflammatory response to antigenic stimulus IEA
GO:0034122 negative regulation of toll-like receptor signaling pathway IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0034122 negative regulation of toll-like receptor signaling pathway IEA
Physiological Functions Comments
Involved in negative regulation of inflammasome signalling, regulation of mucus secretion and host intestinal microbiota composition.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Colitis
Disease:  Colorectal cancer
Disease Ontology: DOID:9256
OMIM: 114500
Disease:  Fatty liver disease, nonalcoholic, susceptibility to, 1; NAFLD1
OMIM: 613282
Role: 
References:  1

References

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1. Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ et al.. (2012) Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature, 482 (7384): 179-85. [PMID:22297845]

Contributors

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How to cite this page

Clare Bryant, Tom Monie.
NOD-like receptor family: NLRP6. Last modified on 22/03/2017. Accessed on 19/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1773.