SLC30 zinc transporter family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Along with the SLC39 family, SLC30 transporters regulate the movement of zinc ions around the cell. In particular, these transporters remove zinc ions from the cytosol, allowing accumulation into intracellular compartments or efflux through the plasma membrane. ZnT1 is thought to be placed on the plasma membrane extruding zinc, while ZnT3 is associated with synaptic vesicles and ZnT4 and ZnT5 are linked with secretory granules. Membrane topology predictions suggest a multimeric assembly, potentially heteromultimeric [2], with subunits having six TM domains, and both termini being cytoplasmic. Dityrosine covalent linking has been suggested as a mechanism for dimerisation, particularly for ZnT3 [1]. The mechanism for zinc transport is unknown.

Transporters

ZnT1 (Zinc transporter 1 / SLC30A1) Show summary »

ZnT2 (Zinc transporter 2 / SLC30A2) Show summary »

ZnT3 (Zinc transporter 3 / SLC30A3) Show summary »

ZnT4 (Zinc transporter 4 / SLC30A4) Show summary »

ZnT5 (Zinc transporter 5 / SLC30A5) Show summary »

ZnT6 (Zinc transporter 6 / SLC30A6) Show summary »

ZnT7 (Zinc transporter 7 / SLC30A7) Show summary »

ZnT8 (Zinc transporter 8 / SLC30A8) Show summary »

ZnT9 (Zinc transporter 9 / SLC30A9) Show summary »

ZnT10 (Zinc transporter 10 / SLC30A10) Show summary »

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Further reading

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References

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How to cite this family page

Database page citation:

SLC30 zinc transporter family. Accessed on 30/07/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=217.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: Transporters. Br J Pharmacol. 170: 1706–1796.