Protein kinase A

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

« Hide

Cyclic AMP-mediated signalling involves regulation of cyclic nucleotide-gated ion channels, members of the Rap guanine nucleotide exchange family (Epac, ENSFM00250000000899) and activation of protein kinase A (PKA, also known as cyclic AMP-dependent protein kinase). PKA is a heterotetrameric enzyme composed of two regulatory and two catalytic subunits, which can be distinguished from Epac (exchange protein directly activated by cyclic AMP, [2]) by differential activation by N6 benzyl-cAMP (see Table) and 8-pCPT-2'-O-Me-cAMP, respectively [3].

Enzymes

Complexes

protein kinase A Show summary » More detailed page

Enzymes and Subunits

PKAR1A (protein kinase, cAMP-dependent, regulatory, type I, alpha subunit) Show summary » More detailed page

PRKAR1B (protein kinase, cAMP-dependent, regulatory, type I, beta subunit) Show summary » More detailed page

PRKAR2A (protein kinase, cAMP-dependent, regulatory, type II, alpha subunit) Show summary » More detailed page

PKAR2B (protein kinase, cAMP-dependent, regulatory, type II, beta subunit) Show summary » More detailed page

PKACa (protein kinase, cAMP-dependent, catalytic, alpha subunit) Show summary » More detailed page

PKACb (protein kinase, cAMP-dependent, catalytic, beta subunit) Show summary » More detailed page

PKACg (protein kinase, cAMP-dependent, catalytic, gamma subunit) Show summary » More detailed page

PRKX (protein kinase, X-linked) Show summary » More detailed page

PRKY (protein kinase, Y-linked, pseudogene) Show summary » More detailed page

Comments

Show »

References

Show »

How to cite this family page

Database page citation:

Protein kinase A. Accessed on 24/05/2016. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=284.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.